DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and chrna11

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001038562.1	Gene:	chrna11 / 566141	ZFINID:	ZDB-GENE-060503-606	Length:	589	Species:	Danio rerio

Alignment Length:	779	Identity:	237/779 - (30%)
Similarity:	347/779 - (44%)	Gaps:	210/779 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            |..:...:..:.:.|..|...|..:.|..:||.:||::.|||.|.:..|||.:.:.|.|::||:.
Zfish     2 WHSLAFTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDE 66

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            |||::|||:|:...|||:.|:|...||.||:.|...:|.:|.|||:|||:||..|:.|..:...:
Zfish    67 KNQVLTTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVV 131

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            |.:|...:.||.|:.|:|.:||.:||||.|.|.:||||||:||:.:||    ::|       ..|
Zfish   132 NSSGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDL----QMN-------EAD 185

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            :|.:..:.|||::.||..|||.||.||.|||.|:||.:|:||:||:|.:||:|||:.:|.:|:|:
Zfish   186 ISGYMPNGEWDLVGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLI 250

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            |.||:|||||:||.|::|||||||.||:|||:|.||..:||:|::....||:...|:..||:||.
Zfish   251 FLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATVVVLQ 315

  Fly   328 IHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPP 392
            .|...|....|..||:.|.:..:..||.|:||                        .:...|..|
Zfish   316 YHHHDPNGGNMPKWVQLVLLQWVAWFLRMKRP------------------------GESEDPERP 356

  Fly   393 PVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQT 457
            |.|                |||:          .|..|...|                |..|...
Zfish   357 PCA----------------PHLR----------RCSSGSQSG----------------SLPNAPG 379

  Fly   458 STTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQT----GQNGSGNGNGNGGYGGHGQ 518
            |.::.|    :|:....|     .|||.|....|..:.:..|    .|..|.|.|||..|.|
Zfish   380 SASADL----HHHHISST-----LHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIG--- 432

  Fly   519 SGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCS 583
                            ||.|.:                |:|..:              ||||.
Zfish   433 ----------------FSSLDE----------------ASPPAL--------------LADSV-- 449

  Fly   584 GTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGP 648
                                                          ||.:.|          |||
Zfish   450 ----------------------------------------------QRNSMS----------GGP 458

  Fly   649 STSAAAAAAAAAAAAG-------TPPPPPPPAGVCDILPACQREGGPHC-CSGRGNVRQRWHTCP 705
            ..:..:.....::...       :|||||.|.......|:....||..| |||......     |
Zfish   459 RPTVVSPPVVGSSPPPHLPSQFCSPPPPPTPNLEATGCPSTVSGGGGGCSCSGTSGGGD-----P 518

  Fly   706 ELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYD 769
            :|...::.|.|:||:.|.::|:..|.|.||:.|.|:|||.|..|::..::.|..|::.||...:
Zfish   519 QLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVIDRLCLVAFSVFNIICTISILMSAPNFVE 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	94/214 (44%)
		Neur_chan_memb	248..>359	CDD:280999	52/110 (47%)
		Neur_chan_memb	<683..760	CDD:280999	26/77 (34%)
chrna11	NP_001038562.1	LIC	2..577	CDD:273305	235/772 (30%)
		Neur_chan_LBD	25..229	CDD:280998	94/214 (44%)
		Neur_chan_memb	236..573	CDD:280999	132/523 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910