DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and chrna4b

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001041528.1	Gene:	chrna4b / 556619	ZFINID:	ZDB-GENE-090505-3	Length:	627	Species:	Danio rerio

Alignment Length:	795	Identity:	286/795 - (35%)
Similarity:	389/795 - (48%)	Gaps:	218/795 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFQVTIDMILVLSFISSSTANPDA-KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVN 66
            :|.:.:.:.|...| |.|.|:..| :||...|..|||||.|||.|::|.:.|...|.::|||||:
Zfish     8 FFLLCVHLQLAYVF-SMSPAHAHAEERLLQSLFINYNKLSRPVANISDVVLVHFGLSIAQLIDVD 71

  Fly    67 LKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKAT 131
            .|||:||||:||:|.|.||||:|.|:||..|..:.:||:.||||||||||||||:|.||..|||.
Zfish    72 EKNQMMTTNVWVKQEWNDYKLRWNPEEYENVTSIRIPSEIIWRPDIVLYNNADGDFAVTHLTKAQ 136

  Fly   132 LNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGV 196
            :.|.||::|:|||||||||.|||.:||||:|.|.|||||||||..::||..:..         .|
Zfish   137 VFYNGRIKWKPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDRAKIDLISMAS---------DV 192

  Fly   197 DLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTIL 261
            |..:::.|.||.|:......|.|.|.||.|.|.|||::..:||..||||:||||||:.||.||:|
Zfish   193 DQMDYWESGEWVIINAVGTYNIKKYECCTEIYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVL 257

  Fly   262 VFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVL 326
            ||||||:..||::|.||:|||||||.||:.||||.||||:||:|:::|||||..|.||.:||.||
Zfish   258 VFYLPSECAEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVL 322

  Fly   327 NIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPIS---------EMI---KSSRRLMVRTCN 379
            |:|.||.:||:|..|||.:|::.:||:|.|:||  |.|         ||:   .:|:.:.:|. |
Zfish   323 NVHHRSSRTHSMPHWVRQLFLHLVPRYLFMKRP--PASGKRNCGKLIEMMHKQANSQSMFLRN-N 384

  Fly   380 GLELRDQ--IPPLPPPVA-----LSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGAST 437
            .|::..|  ||.|.|..|     :.:...|||.....:||..|     |:::.|
Zfish   385 ILDISPQSPIPHLGPTSAAQQDQVQQDSTSPKPLFFCSSPSSQ-----YSILQE----------- 433

  Fly   438 ITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQN 502
                           .|.||                         |.||.    ::.|.:.|
Zfish   434 ---------------ENSQT-------------------------PQTPV----LSYTCAYT--- 451

  Fly   503 GSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTT- 566
                                                    :...||:|||     .|:.:..|.
Zfish   452 ----------------------------------------NSIFASSTTS-----FPDTLLGTLL 471

  Fly   567 -TVNSVATASTLADSCCSGTIQIHQG-----------MGAGAA--CQSSELLHHQQLHHQQMHHQ 617
             |:......||..|      .|.|..           :|||:.  |.:||....|:|
Zfish   472 HTIPQDGAKSTECD------FQGHSAESVFMEAKESVLGAGSCQHCLTSEGTSLQKL-------- 522

  Fly   618 QQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPAC 682
             ...:..:...|..|         :|....||:..:....||...:
Zfish   523 -DLDEAGRCTRHNMP---------SAQIFSPSSDGSTDLNAAEPVS------------------- 558

  Fly   683 QREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLW 747
                         |:.|      .|.||::||.||||..|.|:....|:|||||||||:||:|||
Zfish   559 -------------NLSQ------SLLKALEGVQYIADHLRAEDSDFSVREDWKYVAMVIDRIFLW 604

  Fly   748 IFTIAVVVGTAGIIL 762
            :|.:..::||.|:.|
Zfish   605 MFVLVCILGTVGLFL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	114/215 (53%)
		Neur_chan_memb	248..>359	CDD:280999	68/110 (62%)
		Neur_chan_memb	<683..760	CDD:280999	31/76 (41%)
chrna4b	NP_001041528.1	Neur_chan_LBD	31..237	CDD:280998	113/214 (53%)
chrna4b	NP_001041528.1	Neur_chan_memb	244..618	CDD:280999	160/546 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.770