DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and chrna10a

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_021337092.1	Gene:	chrna10a / 556507	ZFINID:	ZDB-GENE-060503-725	Length:	532	Species:	Danio rerio

Alignment Length:	747	Identity:	201/747 - (26%)
Similarity:	298/747 - (39%)	Gaps:	259/747 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWE 90
            |::|.:||.:||...:|||.:..|.|.|.:::.|||:||::.:|||:|..||:.|.|.|..|.|.
Zfish    30 AQKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQIIDMDERNQILTAYLWIRQVWIDKYLTWN 94

  Fly    91 PKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVE 155
            .:.|.|::.:.:|..::|||||||||:||.:|..|:.|...:.:.|::.|..|||.||||::||.
Zfish    95 KENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDTNVVIRHDGQIMWDAPAITKSSCKVDVS 159

  Fly   156 YFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKF 220
            :||||.|.|.:.:|||||:|.|:|:        .|.:| ..||::...:|||::|.:||.||...
Zfish   160 FFPFDAQQCRLTYGSWTYNGNQLDI--------LNAME-SADLADLVDNVEWEVLGMPAKRNIIL 215

  Fly   221 YTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTV 285
            |.||.:||.|:|:.:.::|:..||..||:|||:.||||..|.||||:||||||||.::::|:|||
Zfish   216 YGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPADSGEKVSLGVTVMLALTV 280

  Fly   286 FFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQL 350
            |.||:|||:|| |..|||:||:.:.||.:.|.|..:|:.|:|||...|....:..|.:...:..|
Zfish   281 FQLLVAEIMPP-SENVPLIGKYYIATMTMITASTALTIFVMNIHHCGPDAKPVPDWAKKFILQYL 344

  Fly   351 PRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQ 415
            .|...    :|.:.|...:.:                |..|.|              :...|
Zfish   345 ARICF----VYEVGENCMTPQ----------------PEKPDP--------------QPQKP--- 372

  Fly   416 HRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLL 480
                     .:|...|.|.|    |....::   ....||:.::...|.|.:..:|......||.
Zfish   373 ---------QDCNCNMNGQA----GKDDFVF---KFDRNQEATSPKLLEDREDMSQILSPACSLG 421

  Fly   481 DHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQA 545
            .||
Zfish   422 KHP-------------------------------------------------------------- 424

  Fly   546 HASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLH 610
                 |...|:....|..|.              .|..|
Zfish   425 -----TCRYGVWKEGVFMSM--------------DCGDG-------------------------- 444

  Fly   611 HQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGV 675
                                                             ||..|.|
Zfish   445 -------------------------------------------------AAETGKP--------- 451

  Fly   676 CDILPACQREGGPHCCSGRGNVRQRWH--------TCPELHKAMDGVTYIADQTRKEEESTRVKE 732
                            .|||....|.|        .|.:.| .:..:.|:|:..|.:..:.|...
Zfish   452 ----------------IGRGQEGCRDHDSGFKSQCKCDQQH-LLRNIEYVANCYRDQRATARRTG 499

  Fly   733 DWKYVAMVLDRLFLWIFTIAV------VVGTA 758
            :||.||.||||.|:|:|.|.|      ::|.|
Zfish   500 EWKKVAKVLDRFFMWLFFIMVFFMSLLIMGKA 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	90/214 (42%)
		Neur_chan_memb	248..>359	CDD:280999	52/110 (47%)
		Neur_chan_memb	<683..760	CDD:280999	26/90 (29%)
chrna10a	XP_021337092.1	Neur_chan_LBD	31..422	CDD:332142	162/453 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810