Protein Alignment nAChRalpha3 and chrna6

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001036149.1
• Gene: chrna6 / 555747
• ZFINID: ZDB-GENE-090312-91
• Length: 512
• Species: Danio rerio
• Alignment Length: 761
• Identity: 250/761 - (32%)
• Similarity: 340/761 - (44%)
• Gaps: 263/761 - (34%)

  Fly     5 QVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKN 69
            :||:..:|:........::....||:..|...||:.:|||.||:|.:||..::.:|||:.|:..|
Zfish     6 RVTLFFLLITLITQDCFSSKGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVN 70

  Fly    70 QIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNY 134
            |||.||||:...|.||||||.|.|:.|:|.:.|||:.||||||||||||.|:|.|...|||.|.:
Zfish    71 QIMETNLWLRHIWNDYKLKWSPAEFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKF 135

  Fly   135 TGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG--VD 197
            .|.:.|.||||:||||.:|:.|||||.|.|.|||||||||..::||           |.:|  |:
Zfish   136 DGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDL-----------VLIGSKVN 189

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            |.:|:.|.||:|::.|..:::..|.||:|.|.|||::..:||..||||:||||||:.|||||:||
Zfish   190 LKDFWESGEWEIIDAPGYKHDIKYNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTVLV 254

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            ||||||.||||:|.||:|||||||.|::.|.||.||||:||:|:::|||||..|.||.:||.|||
Zfish   255 FYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN 319

  Fly   328 IHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPP 392
            :|:|:|.||||..||.|||:..|||.::|||||    ::.:||
Zfish   320 VHYRTPMTHTMPSWVHTVFLRALPRIMLMRRPL----DLSESS---------------------- 358

  Fly   393 PVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQT 457
                                                 |.||
Zfish   359 -------------------------------------GKGG------------------------ 362

  Fly   458 STTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGH 522
                           .:||||                         ||.|.|.||.|...::.|
Zfish   363 ---------------LETGGS-------------------------SGTGAGRGGEGKKRKNSG- 386

  Fly   523 HLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQ 587
               .||.:                                     :||:......|
Zfish   387 ---SQQGA-------------------------------------MNSLEFGEGKA--------- 402

  Fly   588 IHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSA 652
            ..:|...|..|                                .|...|........:...|..|
Zfish   403 ALEGKKGGCPC--------------------------------HPLKEATEGDCGKVSRQLSPQA 435

  Fly   653 AAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYI 717
            .....|.:..:                                         ||:.:|::.|.||
Zfish   436 INTVVAFSVVS-----------------------------------------PEIKQAIESVKYI 459

  Fly   718 ADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQ 763
            |:..|...::..|::||||||||:||:|||:|.:..|:||.|:.||
Zfish   460 AENMRSRNKAKEVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFLQ 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	107/216 (50%)
		Neur_chan_memb	248..>359	CDD:280999	73/110 (66%)
		Neur_chan_memb	<683..760	CDD:280999	26/76 (34%)
chrna6	NP_001036149.1	LIC	38..504	CDD:273305	242/726 (33%)
		Neur_chan_LBD	38..233	CDD:280998	104/205 (51%)
		Neur_chan_memb	240..503	CDD:280999	133/512 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20888
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.870