Protein Alignment nAChRalpha3 and chrnd

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001015814.1
• Gene: chrnd / 548531
• XenbaseID: XB-GENE-989975
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 463
• Identity: 157/463 - (33%)
• Similarity: 262/463 - (56%)
• Gaps: 48/463 - (10%)

  Fly    10 MILVLSFISSSTANPDAKRLYDDLLS--NYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIM 72
            ::.:.|:.....:..:.:||.:.:..  .|.|.:|||.:..:.:.|.:.|.||.||.:...::.:
 Frog     9 LLPIFSYFQGCLSESEEERLLNHIFGERGYRKELRPVEHTGETVNVSLALTLSNLISLKEADETL 73

  Fly    73 TTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGR 137
            |||:|||..|||.:|.|:.:|:..:.::.||.|.:|:|.::|.||.:|.|||...:...:|..|.
 Frog    74 TTNVWVELGWYDKRLAWDMEEFHHINIIRVPPDMVWQPQLILENNNNGVFEVAYYSNVLVNSDGF 138

  Fly   138 VEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDL---RHIDELNGTN--VVEVGVD 197
            :.|.||||:::||.|:|.|||||.|.|.:||.|.||:..:::|   :..||.:..|  |..:.:|
 Frog   139 MYWLPPAIFQTSCSINVNYFPFDWQNCSLKFSSLTYNAKEINLQLRQDQDEESQRNYPVEWIIID 203

  Fly   198 LSEFYTSVEWDILEVPAVRN-EKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTIL 261
            ...|..:.||:|:.:||.:| ::..|.....|.||||.:.::||.|||.:|::.||:.|:.:..|
 Frog   204 PEGFTENGEWEIVHIPAKKNIDRSLTPESTKYQDITFYLIIKRKPLFYIINILAPCVLIALMANL 268

  Fly   262 VFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVL 326
            |||||:|||||::|:||:||:.:||.||:::.:|.||..:||:.|:::|.|:|.|..:...|:||
 Frog   269 VFYLPADSGEKMTLAISVLLAQSVFLLLISQRLPETSFAIPLISKYLMFIMVLVTIVVVSCVIVL 333

  Fly   327 NIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYP---------------ISEMIKSSRRLMVR 376
            |:|||:|.||.:...::.:|:|:|||.|.|.||..|               :..::|:.....|:
 Frog   334 NLHFRTPSTHVITERMKEIFLNKLPRILHMSRPAEPEPEPWSGVLLRRSSSVGYIVKAEEYYSVK 398

  Fly   377 TCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGG-------G 434
            :.:.|....|          |..|   ..|||:| |...:.:.:.|..|:    :.|       |
 Frog   399 SRSELMFEKQ----------SERH---GLTSRAT-PARVNPLNSNNSQDQ----LYGEIKPAIDG 445

  Fly   435 ASTITGHL 442
            |:.|..|:
 Frog   446 ANFIVKHM 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	81/225 (36%)
		Cys-loop	150..164	CDD:349832	9/13 (69%)
		LGIC_TM_nAChR	242..>331	CDD:349866	42/88 (48%)
		TM1 helix	242..266	CDD:349866	11/23 (48%)
		TM2 helix	274..295	CDD:349866	9/20 (45%)
		TM3 helix	306..328	CDD:349866	8/21 (38%)
		Neur_chan_memb	<683..760	CDD:460753
chrnd	NP_001015814.1	LGIC_ECD	26..248	CDD:475126	80/221 (36%)
		Neur_chan_memb	255..493	CDD:460753	71/217 (33%)