Protein Alignment nAChRalpha3 and NtR

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 412
• Identity: 79/412 - (19%)
• Similarity: 160/412 - (38%)
• Gaps: 63/412 - (15%)

  Fly    12 LVLSFIS-SSTANPDAKRLYDDLLSNYNKLVRPVV---NVTDALTVRIKLKLSQL-IDVNLKN-- 69
            ||::::| ||..:..|:..||.....|...:.|:|   ..|:.|...:.::.... :..||.:
  Fly   176 LVINYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSIS 240

  Fly    70 -QIMTTNLWVEQS-------------WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADG 120
             ...|.:|..||:             |.|.:|.|:|:::|.:|....|...||:|.:.:.|.|..
  Fly   241 FHFQTRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQ 305

  Fly   121 NFEVTLATKATLNY-TGRVEWRPPAIYKSS-CEIDVEYFPFDEQTCVMKFG----------SWTY 173
            :....|.:...:.| .|.:......:..:| |......:|.:..||.::.|          :..|
  Fly   306 SMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIY 370

  Fly   174 DGFQVDL---RHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNI 235
            |..:..:   .|::..:|.:..::.|.|.|..:...::    |....:|...       |:....
  Fly   371 DDQRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYN----PKGMMQKMTG-------DVAIEF 424

  Fly   236 TMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLV 300
            |::|...||.....:|.:......||.|.|.|   .:.|..|.|.|.:..:.|:..........|
  Fly   425 TLQRNRSFYMTVFYLPLIACQMFLILSFVLRS---TRRSSLILIALLIAAWGLMYMTRYASPHYV 486

  Fly   301 VPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMR-------- 357
            .|::..:.:. |:..|:...:.:.::.:....|::......||.:..|.|...|.:|
  Fly   487 PPMMTAYKVI-MMTTTYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRCILGLRFSDSTDYC 550

  Fly   358 ----RPLYPISEMIKSSRRLMV 375
                .|.:.:::::.:...::|
  Fly   551 DIQENPWHHMAKILNNLSSILV 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	48/252 (19%)
		Cys-loop	150..164	CDD:349832	2/13 (15%)
		LGIC_TM_nAChR	242..>331	CDD:349866	17/88 (19%)
		TM1 helix	242..266	CDD:349866	6/23 (26%)
		TM2 helix	274..295	CDD:349866	5/20 (25%)
		TM3 helix	306..328	CDD:349866	2/21 (10%)
		Neur_chan_memb	<683..760	CDD:460753
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	5/14 (36%)
		Neur_chan_LBD	212..429	CDD:460752	41/227 (18%)