Protein Alignment nAChRalpha3 and HisCl1

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 412
• Identity: 96/412 - (23%)
• Similarity: 162/412 - (39%)
• Gaps: 98/412 - (23%)

  Fly    13 VLSFISSSTANPD----AKRLYDDLLSNYNKLV-RPVVNVTDALTVRIKLKLSQLIDVNLKNQIM 72
            ::|...||.:.||    ..:.||.  :...||: :|.|       |...:.:..|..:|.::...
  Fly    46 LVSHYESSLSLPDILPIPSKTYDK--NRAPKLLGQPTV-------VYFHVTVLSLDSINEESMTY 101

  Fly    73 TTNLWVEQSWYDYKLKW-----EPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            .|::::.|||.|.:|:.     |......|:.||    .||||| ..:.||.   :||....:..
  Fly   102 VTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLH----SIWRPD-CFFKNAK---KVTFHEMSIP 158

  Fly   133 NYTGRVEWRPPAIYKS------SCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNV 191
            |:...:......:|.|      ||.:..|.:|.|.|.|.|...|.::.  ..||..|..:....|
  Fly   159 NHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHT--VEDLVFIWNMTDPLV 221

  Fly   192 VEVGV-----DLSEFYT---SVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNL 248
            |...:     |:|..||   ::|:      :..|   :||     |.|.||  :||:..::..:.
  Fly   222 VNTEIELPQLDISNNYTTDCTIEY------STGN---FTC-----LAIVFN--LRRRLGYHLFHT 270

  Fly   249 IIPCMGISFLTILVFYL-PSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPL------LGK 306
            .||...|..::.:.|:: |.....:|:|.::.||:|........:.:||.|.|..:      ...
  Fly   271 YIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSV 335

  Fly   307 FVLFTM----ILDTFSICVTVLVL------NI-----------HFR----SPQTHTMAPWVRT-V 345
            ||..::    :::.|...|....:      ||           |.|    .||..|......| :
  Fly   336 FVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHRESIIEPQYDTFCHGHATAI 400

  Fly   346 FINQLPRFLVMRRPLYPISEMI 367
            :|::..||      .:|.|..|
  Fly   401 YIDKFSRF------FFPFSFFI 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	60/241 (25%)
		Cys-loop	150..164	CDD:349832	5/13 (38%)
		LGIC_TM_nAChR	242..>331	CDD:349866	21/116 (18%)
		TM1 helix	242..266	CDD:349866	4/24 (17%)
		TM2 helix	274..295	CDD:349866	4/20 (20%)
		TM3 helix	306..328	CDD:349866	4/31 (13%)
		Neur_chan_memb	<683..760	CDD:460753
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	54/216 (25%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	16/85 (19%)
		TM1 helix	265..288	CDD:349851	4/22 (18%)
		TM2 helix	292..316	CDD:349851	5/23 (22%)
		TM3 helix	324..350	CDD:349851	2/25 (8%)