DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and chrnd

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_996947.1	Gene:	chrnd / 404273	ZFINID:	ZDB-GENE-030131-6665	Length:	518	Species:	Danio rerio

Alignment Length:	451	Identity:	164/451 - (36%)
Similarity:	241/451 - (53%)	Gaps:	57/451 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DAKRLYDDLLS--NYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 87
            :.:||.:.|..  .|||.:|||.|..:.:.:.:.|.||.||.:...::.:.||:|:|..|.|::|
Zfish    24 EEERLINYLFKERGYNKELRPVQNKDETVDIYLALTLSNLISLKEVDETLLTNVWMEHGWKDHRL 88

  Fly    88 KWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEI 152
            .|...|| .:.:|.:|...:|.|:|||.||.|..|:|.......:..:|.:.|.||||::|||.|
Zfish    89 TWNESEY-DIPVLRLPPSMVWLPEIVLENNNDAQFQVAYYCNVLIYSSGDMYWLPPAIFRSSCSI 152

  Fly   153 DVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG---VDLSEFYTSVEWDILEVPA 214
            :|.|||||.|.|.:||.|.||:..::.|....|...|...:|.   :|...|..:.||:|:..||
Zfish   153 NVNYFPFDWQNCSLKFSSLTYNAKEISLNLKMEQENTTYYKVEWIIIDPEGFTENGEWEIVHKPA 217

  Fly   215 VRNEKFYTCC---DEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLS 276
            .||  .|...   ...:.||||.:.::||.|||.||:||||:.||||..||:|||:|||||::||
Zfish   218 RRN--IYKSIPKESNKHQDITFYLIIKRKPLFYIVNIIIPCVLISFLASLVYYLPADSGEKMTLS 280

  Fly   277 ISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPW 341
            ||:||:.:||.||:::.:|.||:.|||:.|:::|.|:|.|..:...|:|||:|||:|.||.|..|
Zfish   281 ISVLLAQSVFLLLISQRLPETSMAVPLIVKYLMFIMVLVTVVVLNCVIVLNLHFRTPSTHVMTEW 345

  Fly   342 VRTVFINQLPRFLVMRRPL--YPISE--------------------MIKSSRRLMVR---TCNGL 381
            .:..|:.:|||.|.|..|:  .|:.|                    .:||...||..   ..:||
Zfish   346 TKEFFLERLPRLLHMSLPVEDQPVPESALPRRSSSLGYIAQAEEYYSVKSRSELMFEKQSERHGL 410

  Fly   382 ELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHL 442
            ..|.                :||.|..|::.. :...|.||.|...    ..||:.|..|:
Zfish   411 AARP----------------TPKATYTSSNDS-EVSEQLYNEMKPA----VEGANYIVKHM 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	79/222 (36%)
		Neur_chan_memb	248..>359	CDD:280999	57/110 (52%)
		Neur_chan_memb	<683..760	CDD:280999
chrnd	NP_996947.1	LIC	6..493	CDD:273305	164/451 (36%)
		Neur_chan_LBD	25..245	CDD:280998	79/222 (36%)
		Neur_chan_memb	252..490	CDD:280999	79/220 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810