Protein Alignment nAChRalpha3 and SecCl

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 86/443 - (19%)
• Similarity: 176/443 - (39%)
• Gaps: 120/443 - (27%)

  Fly     8 IDMILVLSFISS---------STANPDAKRLYDDLL-------SNYNKLVRPVVNVTDA--LTVR 54
            |.:|||||..:|         ..:..||..|....|       ..|::|.||....:|.  |.:.
  Fly    12 ITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIV 76

  Fly    55 IKLKLSQLIDVNLKNQIMTTNL--WVEQSWYDYKLKWEPKEYGGVEML----HVPSDHIWRPDIV 113
            :|.::......||.:.::...:  .::..:.|.:|.:  |.:...:.:    |: |:.:|.|.|.
  Fly    77 VKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY--KAFNRSDNILGQKHL-SERLWLPHIF 138

  Fly   114 LYNNADGNFEVT--------LATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGS 170
            ..|..:.:...|        |:.:..:..:.|::   .::|   |.::.:.||||:|.|.....|
  Fly   139 FANERESSILGTDEKDVLTSLSPEGNVIISTRMQ---ASLY---CWMNFQKFPFDQQFCSTVLES 197

  Fly   171 WTYD--------------GFQVDLRHIDELNGTNVVEVGVDLSEFY--TSV---EWDILEVPAVR 216
            |.|:              .|..::| :.|.|          :::|:  |::   :.|.|...|..
  Fly   198 WMYNTSDLILEWEPHTPISFDPEMR-LTEYN----------MAQFWHNTTIVQSDGDNLRHGAFA 251

  Fly   217 NEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSD-SGEKVSLSISIL 280
            ..         |..::|.:.::|:..||.::..:|.|.|..::.:.|:|.:| |..::.|..|.:
  Fly   252 GN---------YSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTM 307

  Fly   281 LSLTVFFLLLAEIIPPTSLV----VPLLG-KFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAP 340
            ||........::.:|..|.:    |..|| .|.:|..::: |:...|:
  Fly   308 LSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVE-FAFVNTI----------------- 354

  Fly   341 WVR--TVFINQLPRFLVMRRPLYPISEMIKSSRRLM---------VRTCNGLE 382
            |.|  .:.:.::....:::..|.|     :.:||.:         .|:|:.|:
  Fly   355 WRRKENIELKKVNSKYIIKSTLTP-----RPARRQIGGSLSNESRARSCSSLD 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	48/259 (19%)
		Cys-loop	150..164	CDD:349832	6/13 (46%)
		LGIC_TM_nAChR	242..>331	CDD:349866	22/94 (23%)
		TM1 helix	242..266	CDD:349866	6/23 (26%)
		TM2 helix	274..295	CDD:349866	4/20 (20%)
		TM3 helix	306..328	CDD:349866	4/21 (19%)
		Neur_chan_memb	<683..760	CDD:460753
SecCl	NP_648984.2	LIC	43..505	CDD:455710	76/412 (18%)