DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and pHCl-1

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	143/805 - (17%)
Similarity:	266/805 - (33%)	Gaps:	253/805 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KRLYDDLL--SNYNKLVRPVVNVTD-----------------------ALTVRIKLKLSQLI--- 63
            |.:.|.||  ..|:|.:.|.||..|                       .|||.:.:.|..|.
  Fly   338 KEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPD 402

  Fly    64 DVNLKNQIMTTNLWVEQSWYDYKLKWEPK-EYGGVEMLHVPSDHIWRPDIVLYNNAD-------G 120
            :.:||.::   ...:.|.|.|.:|::..| .|..:..|| ..|.||.||.....:.|       .
  Fly   403 ESSLKYEV---EFLLNQQWNDPRLQYGNKSHYDFLNALH-HHDSIWTPDTYFIMHGDFKDPIIPM 463

  Fly   121 NFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDE 185
            :|.:.:....|:.|..|   |...:   ||:..:..||||:..|.....|.:|:  :..::::.:
  Fly   464 HFALRIFRNGTITYAMR---RHLIL---SCQGSLHIFPFDDPKCSFSMESISYE--EAQIKYVWK 520

  Fly   186 LNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDE-----PYLDITFNITMRRKTLFYT 245
             |..:.:.....|:         .|....::|:.  |.||:     .|..:...:|..|...:|.
  Fly   521 -NDEDTLRKSPSLT---------TLNAYLIKNQT--TACDQNSWRGNYSCLQVELTFTRDRAYYF 573

  Fly   246 VNLIIPCMGISFLT--ILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFV 308
            ..:.||  ||..:|  .:.|:|     |..::...:::.:|.                 :|..|.
  Fly   574 TTVFIP--GIILVTSSFITFWL-----EWNAVPARVMIGVTT-----------------MLNFFT 614

  Fly   309 LFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLY---------PIS 364
            .......|..:...:..:|:..........|..:..|.:|.:.|    :|||:         |::
  Fly   615 TSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGR----KRPLHNVVYRPGENPVT 675

  Fly   365 EMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMH---HSPKTTSRSTSPHLQHRVQTYNLMDE 426
            :.:                         |..|||:.   .||..::.:|.
  Fly   676 QRL-------------------------PAVLSRIGVILASPLASAAATP--------------- 700

  Fly   427 CGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYH----NQYQQTGGSLLDHPLTPT 487
             .|.|.|||:.    :||..|...|:.  .|..|..:.|.:..    .::|:..|.::...:...
  Fly   701 -AMSMMGGATP----MSSGTPAASSSV--ATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNL 758

  Fly   488 KFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLP-----QHAHQAHA 547
            :.|.:...:::                               |.|.:.||.|     :|.::...
  Fly   759 RARSIKRKAAR-------------------------------SPSTSISPHPSGRPTEHIYEEPG 792

  Fly   548 STTT----------SDLGMANPNVIKSTTTV-NSVATASTLADSCCSGTIQIHQGMGAGAACQSS 601
            .:|:          .:|....|...:|:|.: .||||::...      .::|...:...|
  Fly   793 GSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPAL------VVRIEAEIDPEA----- 846

  Fly   602 ELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTP 666
                      :....|..:..::|.....:|....|:.:        ::.|:..:.|......||
  Fly   847 ----------EDKPIQDMEMTERQLSLPLKPPRRKASRS--------NSPASVYSDAFENVEATP 893

  Fly   667 PPPPPPAGVCDILPACQREGGPHC-CSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRV 730
            ......||..:.:.||...||.:. |:...|......||           ::  |.||:|....:
  Fly   894 GEKRQNAGAPNEIVACTTCGGSNSPCTHSANNGCATETC-----------FV--QVRKKEPPHPI 945

  Fly   731 KEDWKYVAMVLDRLFLWIFTIAVVV 755
            :     ||..:|.:....|..|..:
  Fly   946 R-----VAKTIDVIARITFPTAYAI 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	55/254 (22%)
		Neur_chan_memb	248..>359	CDD:280999	17/112 (15%)
		Neur_chan_memb	<683..760	CDD:280999	15/74 (20%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	54/251 (22%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	22/156 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100