DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and chrna1.2

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_012825723.1	Gene:	chrna1.2 / 394991	XenbaseID:	XB-GENE-5932067	Length:	457	Species:	Xenopus tropicalis

Alignment Length:	354	Identity:	179/354 - (50%)
Similarity:	245/354 - (69%)	Gaps:	15/354 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVLSFISSST--ANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            |:..||::..  ::....||..||.:||||:||||....|.:.|.:.|:|.|||:|:..|||::|
Frog     8 LIFFFIAAGPVFSSDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINVDEVNQIVST 72

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139
            |:.::|.|.|..|||:|.:||||:.|.:||..:|.||:||||||||:|.::..||..|.:||::.
Frog    73 NIRLKQQWVDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDFAISKDTKILLEHTGKIT 137

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTS 204
            |.||||:||.|||.|.:||||:|.|.||||:|||||..|.:         |......|||.|..|
Frog   138 WTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDGTLVVI---------NPDRDRPDLSNFMAS 193

  Fly   205 VEWDILEVPAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSD 268
            .||.:.:....::..:|||| |:||||||::..::|..|::.||:||||:..||||.||||||:|
Frog   194 GEWMMKDYRCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTD 258

  Fly   269 SGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSP 333
            ||||::||||:|||||||.|::.|:||.||..|||:||::||||:....||.:||:|:|.|.|||
Frog   259 SGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSP 323

  Fly   334 QTHTMAPWVRTVFINQLPR---FLVMRRP 359
            .||||.||||.:||:.:|.   |..|:||
Frog   324 STHTMPPWVRKIFIDTIPNIMFFSTMKRP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	103/215 (48%)
		Neur_chan_memb	248..>359	CDD:280999	68/113 (60%)
		Neur_chan_memb	<683..760	CDD:280999
chrna1.2	XP_012825723.1	LIC	8..447	CDD:273305	179/354 (51%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	103/217 (47%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110