DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-29

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001317792.1	Gene:	lgc-29 / 3896858	WormBaseID:	WBGene00044528	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	319	Identity:	75/319 - (23%)
Similarity:	144/319 - (45%)	Gaps:	44/319 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLYDDLLSNYNKLVR--------PVVNVT---DALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQS 81
            ||::.|..:|:..:.        |..|.|   ....:.|:|.:.:|::|....:..|........
Worm    40 RLFEKLFKSYDPGINAIYTLHSVPETNGTVHPPRFEITIQLSMMKLVEVVEPEEKATFLFDYRAD 104

  Fly    82 WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVL---YNNADGNFEVTLATKATLNYTGRVEWRPP 143
            |||.:|.|:|::|||:..::||...:|.|:..:   :::....|:......|.|:..|.:.....
Worm   105 WYDTRLSWDPEDYGGINHIYVPRSKVWIPETTIVDCFSSEIKVFDNEYTRYAWLHSNGSIGMYIA 169

  Fly   144 AIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGT---NVVEVGVDLSEFYTSV 205
            ::....|::||..||.|..||.:.|...||   |::...|....||   .|.::|        :.
Worm   170 SVTSVVCQMDVYKFPMDTHTCSVNFLFMTY---QLEEFTIVGKTGTLPRPVEQLG--------NG 223

  Fly   206 EWDILEV-----PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYL 265
            ||.:..:     |.|.|..:.|         .|..|..|...||.|.::||...|:.|:|:..::
Worm   224 EWQMKSIQIAFEPVVDNLTYLT---------KFEATFSRNPGFYIVLVMIPAYFINVLSIVALFM 279

  Fly   266 P-SDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTV 323
            . ::..||.::.::.::|::...::|||.:|.|. .:|:|..:.:.::.:...|:...|
Worm   280 DINNRSEKFTVGMTNIMSMSFILVILAEDLPKTK-NLPILAIYTVTSLAIMLCSLTAVV 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	55/234 (24%)
		Neur_chan_memb	248..>359	CDD:280999	17/77 (22%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-29	NP_001317792.1	LIC	38..>337	CDD:273305	74/317 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810