DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and CG12344

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	91/436 - (20%)
Similarity:	174/436 - (39%)	Gaps:	77/436 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTIDMILVLSFISSST---ANPDAK-RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVN 66
            ::..:..:|.::|.:|   .|..|| |:.  |..||.|.:||.......:.|...:.:..:..:|
  Fly    11 ISFGLGFILMWLSEATEAHMNYTAKPRVV--LPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSIN 73

  Fly    67 LKNQIMTTNLWVEQSWYDYKLK------WEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNF--- 122
            :::.....::::.|.|.:.:|:      .|..:|  |.:|....::.|:||....|:.....
  Fly    74 VEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDY--VTLLPEVFENFWQPDPYFLNSKIAEIATL 136

  Fly   123 -----EVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRH 182
                 .|||....|:.|..|:.    ||.  :|:::.:.:|.|.|.|.:...|::.:..:|.||.
  Fly   137 THKFTSVTLYKNKTVRYAARMH----AII--ACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRW 195

  Fly   183 IDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEP-----YLDITFNITMRRKTL 242
            .|.         ||.|:.....:::::.:...:.....|.    |     :..:|......|:..
  Fly   196 SDS---------GVTLNPELKLLQYNLGQPLELEESDGYM----PEKVGNFSRLTVYFRFERQIG 247

  Fly   243 FYTVNLIIPCMGISFLTILVFYLPSDS-GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGK 306
            .:.:....|...:..|:...|:|..|: ..:|:|.::.:|:|...|  ....|||.:.|..|  .
  Fly   248 HHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMF--TGADIPPVAYVKAL--D 308

  Fly   307 FVLFTMILDTFSIC---VTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIK 368
            ..:...:|..|:..   |.|.||::.::..             :|::|:.|.||     ||.|.|
  Fly   309 LWMAGCMLSVFAALAEFVVVKVLDVQYQYQ-------------VNRIPKVLPMR-----ISNMEK 355

  Fly   369 SSRRLMVRTCNGLELRD----QIPPLPPPVALSRMHHSPKTTSRST 410
             .:...|.:..|..:|.    |.|..|...:|......||...|.:
  Fly   356 -GQCATVASWEGGAVRSRKATQTPTTPGQTSLQGNGGPPKPARRQS 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	47/234 (20%)
		Neur_chan_memb	248..>359	CDD:280999	26/114 (23%)
		Neur_chan_memb	<683..760	CDD:280999
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	91/436 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100