Protein Alignment nAChRalpha3 and acr-25

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001023570.2
• Gene: acr-25 / 3565563
• WormBaseID: WBGene00043066
• Length: 544
• Species: Caenorhabditis elegans
• Alignment Length: 785
• Identity: 194/785 - (24%)
• Similarity: 311/785 - (39%)
• Gaps: 263/785 - (33%)

  Fly     1 MKWFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDV 65
            |::..:.:.:.|:|:...:.........||.:||.:|..|.||:.|.::|:.|::.|.|.|::||
 Worm     1 MEYCWLILKLCLLLALGRNGITQKSEGDLYTELLEDYEPLERPIENSSEAVMVKMGLVLQQIVDV 65

  Fly    66 NLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKA 130
            :.|||::..|.|::.||.||.|||:|::||||..|......:|.||:::||:||..|:...|:..
 Worm    66 DEKNQVVDVNAWLKFSWVDYSLKWKPEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFDSRYASNL 130

  Fly   131 TLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG 195
            .:...|.|.|.||.:|:.||:|.|.:||||.|.|.:||||||:||.:::|...|.         |
 Worm   131 LVYPNGLVNWMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLEIDDN---------G 186

  Fly   196 VDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
            .|:|.:..:.||.:......||.::|.||.|||.|:.|...:||:.|:|..|||:||:.|:.||:
 Worm   187 FDISNYMQNGEWTLEGTTVKRNIQYYQCCPEPYYDLVFTFVIRRRALYYAFNLILPCILITMLTL 251

  Fly   261 LVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICV--TV 323
            :.|..|.|:|||:||.|:|:||:.:|...:||:.||||..||.|..|  |.:.|.|.:.||  |.
 Worm   252 VGFTFPPDAGEKMSLQITIMLSICIFQNYVAELSPPTSEAVPFLSAF--FAVCLFTCACCVTATT 314

  Fly   324 LVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRD--- 385
            |.||.|.|:.::|.|....|.:.:..:|..|:||||.|             |..|..:..:|
 Worm   315 LALNFHHRTGKSHQMNNTFRLLMLEWIPWLLMMRRPGY-------------VARCGKIVKQDDSE 366

  Fly   386 -------------QIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGAST 437
                         :|..:...:.:.         |...:|....||   .::||...
 Worm   367 DEFEERQTRLDQQRIATIISQITVE---------SNKPTPTFPRRV---TIVDEVNS-------- 411

  Fly   438 ITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQN 502
             .|......||. ....::....:|:.|                    |..:|. |:|:||..|:
 Worm   412 -DGEAEEPLPPD-EVIREEDDDVASMDD--------------------PPAWRS-TTTTSQPPQS 453

  Fly   503 GSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTT 567
            .:                  ||:...::...|..|:.|.|
 Worm   454 PA------------------HLWWNATNRMGNRVPVEQIA------------------------- 475

  Fly   568 VNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRP 632
                                              :||..||:|
 Worm   476 ----------------------------------QLLVLQQVH---------------------- 484

  Fly   633 TTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNV 697
                                                                          |::
 Worm   485 --------------------------------------------------------------GHL 487

  Fly   698 RQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIIL 762
                   .|::|          ..|:.|:|.::::|||:.|:|:||:.:.|||..:...|..:..
 Worm   488 -------SEINK----------HIREREKSKKIEDDWKFSALVVDRICMVIFTSFLFGSTVALFA 535

  Fly   763 QAPTL 767
            ..|.:
 Worm   536 SVPNI 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	86/214 (40%)
		Neur_chan_memb	248..>359	CDD:280999	48/112 (43%)
		Neur_chan_memb	<683..760	CDD:280999	17/76 (22%)
acr-25	NP_001023570.2	Neur_chan_LBD	26..231	CDD:280998	85/213 (40%)
		Neur_chan_memb	239..534	CDD:280999	101/530 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910