DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-28

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001022053.1	Gene:	lgc-28 / 3565225	WormBaseID:	WBGene00044301	Length:	397	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	66/387 - (17%)
Similarity:	140/387 - (36%)	Gaps:	92/387 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DAKRLYDDLL----SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDY 85
            |..:.:||.:    ..|.:|: |:::|            ..:.|:..:..::...|....:|.|.
Worm    39 DITKRFDDTMPIKKDGYLQLI-PLLHV------------DHIHDIQDEQGVLKMALTFTFTWMDE 90

  Fly    86 KLKWEPKEYGGVEMLHVPSDHIWR-----PDIVLYNNADG----------NFEVTLATKATLNYT 135
            :|.|.|..|.|:.........:||     |.:::.:..:.          :.::.:::...:..:
Worm    91 RLMWNPSNYSGIRTFSTTRHEMWRKKFWTPTLMMTDVPNSRRPSDVFKPFDMDIYISSSGMVRTS 155

  Fly   136 GRVEWRPPAIYKSSCEIDVEYFPFDEQTCV-----------MKFGSWTYDGFQVDLRHIDELNGT 189
            .|:....|      |......:|.|.:.|.           .:|..|   |.....|::.....|
Worm   156 ARMMLTIP------CRTGFGSYPNDYKNCTFTLMSPYYADQFRFAQW---GGAEFTRYLMSSRVT 211

  Fly   190 NVVE---VGVDLSEFY----TSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVN 247
            :|::   :.:|...:|    :.|..|..:........||          .:|:.::|...|.:|.
Worm   212 DVLDFQLINIDTRNYYMFLGSEVVDDFSKFKPRHCRSFY----------RYNLVLKRVNKFVSVQ 266

  Fly   248 LIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTM 312
            ||.|...|:....:..:||...|  :..:.|.|:..|:|...:.:::|.....:|::...:.|
Worm   267 LIAPISVIAVFLAISGFLPHFYG--LVCAGSALVYETIFTYDVEQVLPKDYSGMPMIAILLCF-- 327

  Fly   313 ILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLM 374
               .|:..:.:|...:...:.::||    |.|.|            |.|...|:.....:|:
Worm   328 ---LFAETIVLLAWKVFSINTRSHT----VFTAF------------PEYFDDEITSKKEKLL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	38/251 (15%)
		Neur_chan_memb	248..>359	CDD:280999	21/110 (19%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	19/142 (13%)
		LIC	67..>329	CDD:273305	48/287 (17%)
		Cys-loop	164..178	CDD:349787	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810