Protein Alignment nAChRalpha3 and deg-3

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001379138.1
• Gene: deg-3 / 3565200
• WormBaseID: WBGene00000951
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 781
• Identity: 171/781 - (21%)
• Similarity: 279/781 - (35%)
• Gaps: 292/781 - (37%)

  Fly    19 SSTANPDAK-------RLYDDLLS--NYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            :|||:.|..       ||...|||  .|:..|||:::...:|.|.|.:.|.|:|:|:..:|.:..
 Worm    37 NSTADRDIAMKNVPLVRLTRHLLSPERYDVRVRPILDHKKSLKVHISISLYQIIEVDEPSQNIKL 101

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT---LATKATLNYTG 136
            |:|:.|.|.|..|.|.|.|||.:....:|..|:|.||..|||:...:.:.|   :..:||.||
 Worm   102 NVWMIQKWRDEYLDWNPNEYGMINSTIIPFHHLWIPDTYLYNSVKMSRDETERYMNIQATSNY-- 164

  Fly   137 RVEWRP----------PAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNV 191
               |:.          ||||..:|.:::.:||:|.|.|.:...|||.....:|.          .
 Worm   165 ---WKGEKGAELSFLYPAIYTITCRLNIRFFPYDRQNCTLTISSWTNSKSALDY----------Y 216

  Fly   192 VEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGIS 256
            .:..|.:..|..:.||.:......|:|..|.||.||::.:..::.::||.|:|.||||||...|:
 Worm   217 ADTEVSMQSFIPNEEWQVKSFKIHRHEYKYACCAEPWVILQASLVIQRKPLYYLVNLIIPTSIIT 281

  Fly   257 FLTILVFYLPS----DSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTF 317
            .:.|..|:.|:    |..||::|.|:.||::::..|::::.:|.||..|||:..|.|..:|:.:.
 Worm   282 LVAITGFFTPASTDDDRTEKINLGITTLLAMSILMLMVSDQMPTTSEFVPLIAWFYLSIIIIISI 346

  Fly   318 SICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLE 382
            ...:|.:||::..|.........::|.:|...||:.|::.
 Worm   347 GTFLTSVVLSVQGRRQYGRNPPQFIRYIFFVLLPQVLLLN------------------------- 386

  Fly   383 LRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYP 447
                   :|||:
 Worm   387 -------VPPPL----------------------------------------------------- 391

  Fly   448 PTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGG 512
                                     |...|.|.|.||...:.::
 Worm   392 -------------------------QTLWGELDDDPLNVRRRKK--------------------- 410

  Fly   513 YGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTL 577
                    .|:|.|..::.|..                     ||:|
 Worm   411 --------SHYLSRNVNNGSTK---------------------MASP------------------ 428

  Fly   578 ADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAA 642
                 ..|:::.|..|:                   :..::|..|.........|.|:.:.|.:.
 Worm   429 -----MSTLRVPQSAGS-------------------VSEKRQSFQMIDVTSPNSPNTARSRAPSL 469

  Fly   643 AAAGGPSTSAAAA-AAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPE 706
            |    |||:.|.. ....:|.|||                              |.:.| .|...
 Worm   470 A----PSTAKATMWEGTMSALAGT------------------------------NTQLR-RTSNV 499

  Fly   707 LHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIIL---QAPTLY 768
            .:|.:|      :..||.:.|.    :|:::|.||||..|.:|..|||:.|||:||   .|...|
 Worm   500 FNKEVD------EMRRKRQCSL----EWEFLATVLDRFLLIVFVGAVVIVTAGLILVGRMAQYSY 554

  Fly   769 D 769
            |
 Worm   555 D 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	70/239 (29%)
		Cys-loop	150..164	CDD:349832	5/13 (38%)
		LGIC_TM_nAChR	242..>331	CDD:349866	32/92 (35%)
		TM1 helix	242..266	CDD:349866	11/23 (48%)
		TM2 helix	274..295	CDD:349866	5/20 (25%)
		TM3 helix	306..328	CDD:349866	6/21 (29%)
		Neur_chan_memb	<683..760	CDD:460753	21/76 (28%)
deg-3	NP_001379138.1	Neur_chan_LBD	53..266	CDD:460752	68/227 (30%)
		LGIC_TM_cation	267..>357	CDD:349853	32/89 (36%)
		TM1 helix	267..291	CDD:349853	11/23 (48%)
		Neur_chan_memb	273..543	CDD:460753	88/516 (17%)
		TM2 helix	303..324	CDD:349853	5/20 (25%)
		TM3 helix	335..357	CDD:349853	6/21 (29%)