DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-8

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001023533.2	Gene:	lgc-8 / 3564870	WormBaseID:	WBGene00013338	Length:	438	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	88/345 - (25%)
Similarity:	166/345 - (48%)	Gaps:	38/345 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            |..:.||.|.|            :::|.|.|:..|:..:|||:|..|.|.:.|.:.....:.::.
Worm    17 WNLLEIDGITV------------SEQLKDVLMEGYDSSIRPVINERDTLFINISINSMSFLTLDP 69

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATK-AT 131
            ..:.:..:......|.|..|.|...:| .:..|.:....:|.||..:..:.|.|:.:..:.: .:
Worm    70 AEETINFSGEFILQWKDEFLFWNKSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIETSERYVS 133

  Fly   132 LNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGV 196
            :.|.|.|.....|::.:.|::::..||:|:|||::|.|.|:|     .::.:..:.|.: :|...
Worm   134 VKYDGTVRQNIYAVFTNLCDMNINEFPYDQQTCMIKMGPWSY-----TMKEVTCIVGGD-IERNE 192

  Fly   197 DLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFN-----ITMRRKTLFYTVNLIIPCMGIS 256
            ...:|..:.|||...:.:...|     .::|.::.||:     :|::|:..||...|:||...|:
Worm   193 TTGKFQGNSEWDFEGIVSSVGE-----TEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIIT 252

  Fly   257 FLTILVFYLPSDS----GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTF 317
            .:.|...:.|:.:    .|:|:|.|:.|||..|...::|..:|.|| .:||||.|:|..:.:...
Worm   253 VVCIFGLFTPTANHGLREERVNLGITTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAI 316

  Fly   318 SICVTVLVLNIHFRSPQTHT 337
            .:...||||.:|.|:   ||
Worm   317 GVLFAVLVLTLHQRA---HT 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	49/220 (22%)
		Neur_chan_memb	248..>359	CDD:280999	32/94 (34%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-8	NP_001023533.2	Neur_chan_LBD	29..237	CDD:280998	49/219 (22%)
lgc-8	NP_001023533.2	Neur_chan_memb	244..>348	CDD:280999	32/94 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810