DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and ZACN

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_851321.2	Gene:	ZACN / 353174	HGNCID:	29504	Length:	412	Species:	Homo sapiens

Alignment Length:	347	Identity:	66/347 - (19%)
Similarity:	139/347 - (40%)	Gaps:	66/347 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTD----ALTVRIKLKLSQLID 64
            |.:|:.::....|..::...|....:      |.:|.|:..:.:.:    .|.|.:::.:|.:.:
Human    15 FSITLLLVHGQGFQGTAAIWPSLFNV------NLSKKVQESIQIPNNGSAPLLVDVRVFVSNVFN 73

  Fly    65 VNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYN------------- 116
            |::....|::.|.:..||.|.:|.|....:.. ..:.:|.:.:|.|.:.:..
Human    74 VDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEALWVDWRDQSPQA 137

  Fly   117 --NADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVD 179
              :.||:.::.||.....|                |..::.:||.|...|.:.|.:.:....:::
Human   138 RVDQDGHVKLNLALATETN----------------CNFELLHFPRDHSNCSLSFYALSNTAMELE 186

  Fly   180 LRHIDELNGTNVVEVGVDLSEFYTSVEWDI-LEVPAVRNEKFYTCCDEPYLDITFNITMRRK--T 241
            .:       .:||...|.:...|  |.:|: .:||.   ::...|         |.:|:|.|  .
Human   187 FQ-------AHVVNEIVSVKREY--VVYDLKTQVPP---QQLVPC---------FQVTLRLKNTA 230

  Fly   242 LFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGK 306
            |...:.|::|...:....:....||..:.|::...:::|||..|....|.:.:|.:|...|||..
Human   231 LKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIY 295

  Fly   307 FVLFTMILDTFSICVTVLVLNI 328
            :....::|...|...|||:..:
Human   296 YFTILLLLLFLSTIETVLLAGL 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	41/236 (17%)
		Neur_chan_memb	248..>359	CDD:280999	20/81 (25%)
		Neur_chan_memb	<683..760	CDD:280999
ZACN	NP_851321.2	LIC	11..368	CDD:273305	66/347 (19%)
		Neur_chan_LBD	54..>187	CDD:280998	25/149 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900