DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and nAChRalpha6

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	785	Identity:	218/785 - (27%)
Similarity:	316/785 - (40%)	Gaps:	309/785 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            :::.|:.|..|...|..|||.:.|||.||.|.|||.|.::.|.|:..|.|.|:|||:.||||:||
  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139
            |.|:...|.||.|:|...|||||:.|.:..:.:|:||:::||:||..|:.|..|...:.:.|...
  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTS 204
            :.||.|:||:|:||:.:||||:|.|.||||||||||.|:||    .||.    |.|.|||:|.|:
  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL----VLNS----EDGGDLSDFITN 200

  Fly   205 VEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS 269
            .||.:|.:|..:|...|.||.|||:||||.|.:||:||:|..|||:||:.||.:.:|.|.||.||
  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265

  Fly   270 GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTM-------------------ILD 315
            |||::|.::||||||||..|:||.:|.||..|||:|..:|.::                   :|.
  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330

  Fly   316 TF----------SICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSS 370
            |:          |:.:||:|||.|.|:...|.|.||:::||:..||..|.|.||          .
  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP----------G 385

  Fly   371 RRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGA 435
            |::..:|                :.||......:...||:...|.      |::|
  Fly   386 RKITRKT----------------ILLSNRMKELELKERSSKSLLA------NVLD---------- 418

  Fly   436 STITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTG 500
                                        ||..:.:                      |.:.|||.
  Fly   419 ----------------------------IDDDFRH----------------------TISGSQTA 433

  Fly   501 QNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKST 565
             .||                           ||:|.                           ..
  Fly   434 -IGS---------------------------SASFG---------------------------RP 443

  Fly   566 TTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQ 630
            |||                                                       ::||
  Fly   444 TTV-------------------------------------------------------EEHH--- 450

  Fly   631 RPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRG 695
                                          .|.|                          |:.:
  Fly   451 ------------------------------TAIG--------------------------CNHK- 458

  Fly   696 NVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGI 760
                      :||..:..:.:|..:.||.::...:..|||:.|||:||..|.:||:..::.|..:
  Fly   459 ----------DLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTV 513

  Fly   761 ILQAP 765
            :|.||
  Fly   514 LLSAP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	105/214 (49%)
		Neur_chan_memb	248..>359	CDD:280999	55/139 (40%)
		Neur_chan_memb	<683..760	CDD:280999	18/76 (24%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	216/782 (28%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	91/188 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940