Protein Alignment nAChRalpha3 and HTR3A

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_998786.3
• Gene: HTR3A / 3359
• HGNCID: 5297
• Length: 510
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 123/459 - (26%)
• Similarity: 209/459 - (45%)
• Gaps: 90/459 - (19%)

  Fly     3 WFQVTIDMILVLSFI-------SSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLS 60
            |.|..:..:|:.:.:       |.:|..|...||.|.||:||.|.||||.:.....||.|.:.:.
Human     4 WVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 68

  Fly    61 QLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT 125
            .:::|:.|||::||.:|..|.|.|..|:|.|:::..:..|.:|:|.||.|||::      |..|.
Human    69 AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI------NEFVD 127

  Fly   126 LATKATLNYT-----GRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSW--TYDGFQVDLRHI 183
            :.....:.|.     |.|:...|....::|.:|:..||||.|.|.:.|.||  |.....:.|..:
Human   128 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRL 192

  Fly   184 DELNGTNVVEVGVDLSEFYTSVEWDILEV-PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVN 247
            .|       :|..|.|.|....||::|.| |..|  :|.......|.::.|.:.:||:.|||.|:
Human   193 PE-------KVKSDRSVFMNQGEWELLGVLPYFR--EFSMESSNYYAEMKFYVVIRRRPLFYVVS 248

  Fly   248 LIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGK------ 306
            |::|.:.:..:.|:.||||.:|||:||..|::||..:||.:::::.:|.|::..||:||
Human   249 LLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSR 313

  Fly   307 --------------------------FVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTV 345
                                      :.:..|.|...|:..|:.::.:..:......:..|:|.:
Human   314 AQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHL 378

  Fly   346 FINQLPRFLVMR------RPLYPISEMIKSSRRLMVRTCNGL---------------ELRDQIPP 389
            .:.::...|.:|      ||  |     .:|:......|:.:               ..||:..|
Human   379 VLERIAWLLCLREQSTSQRP--P-----ATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSP 436

  Fly   390 LPPP 393
            .|||
Human   437 PPPP 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	71/225 (32%)
		Cys-loop	150..164	CDD:349832	7/13 (54%)
		LGIC_TM_nAChR	242..>331	CDD:349866	31/120 (26%)
		TM1 helix	242..266	CDD:349866	9/23 (39%)
		TM2 helix	274..295	CDD:349866	6/20 (30%)
		TM3 helix	306..328	CDD:349866	5/53 (9%)
		Neur_chan_memb	<683..760	CDD:460753
HTR3A	NP_998786.3	LIC	23..504	CDD:273305	120/440 (27%)