DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and nAChRbeta3

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster

Alignment Length:	333	Identity:	97/333 - (29%)
Similarity:	174/333 - (52%)	Gaps:	30/333 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QVTIDMILV-LSFISSSTANPDAK--------RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLS 60
            |:.:.|:|: |:.:..:||..|.|        ||:..|.:||:..|:||...|.. .|.:::.::
  Fly    21 QMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPT-NVSLEMVVT 84

  Fly    61 QLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT 125
             .||::..|..:||:.|:...|.|.:..|:|.:|..:..:.:.|..:|.|.|.|:|..:|.  :.
  Fly    85 -YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG--LM 146

  Fly   126 LATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTN 190
            ..|:.||::.|...|.|||:|.:.||:::..:|.|:|:|.:|.|||   |.:|.|..    |||.
  Fly   147 AETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPE----NGTA 204

  Fly   191 VVEVGVDLSEFYTSVEWDILEVPA-VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMG 254
            ..| .:|..:...|.||:|::..| ..::.:|     .|::.|  :|.:|::..||..:..|...
  Fly   205 RGE-SLDHDDLVQSPEWEIVDSRAHFVSQDYY-----GYMEYT--LTAQRRSSMYTAVIYTPASC 261

  Fly   255 ISFLTILVFYLPSD-SGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFS 318
            |..|.:..|:||.. .|||:.::..:::.:..|.:..|:::|..|...||:..|...:::..:.|
  Fly   262 IVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVS 326

  Fly   319 ICVTVLVL 326
            ..|.||||
  Fly   327 TIVEVLVL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	66/223 (30%)
		Neur_chan_memb	248..>359	CDD:280999	22/80 (28%)
		Neur_chan_memb	<683..760	CDD:280999
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	92/315 (29%)
		Neur_chan_LBD	52..247	CDD:280998	64/213 (30%)
		Neur_chan_memb	255..434	CDD:280999	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840