Protein Alignment nAChRalpha3 and Lcch3

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 478
• Identity: 86/478 - (17%)
• Similarity: 176/478 - (36%)
• Gaps: 134/478 - (28%)

  Fly    32 DLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKW------- 89
            ::|..|:..:||... .:.|.|.:.|.::....::..|...|..:::.|.|.|.:|.:
  Fly    46 NILQGYDIRLRPNFG-GEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYF 109

  Fly    90 -EPKEYGGVEMLHVPSD---HIWRPDIVLYNNADGNF--EVTLATK-ATLNYTGRVEWRPPAIYK 147
             :..:.|..::|.:..|   .||.|| ..:.|...:|  :||...| ..|...|.|.:.......
  Fly   110 DDENDDGISDVLTLSGDFAEKIWVPD-TFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTT 173

  Fly   148 SSCEIDVEYFPFDEQTCVMKFGSWTYDGFQV-------DLRHIDELNGTNVVEVGVDLSEFYTSV 205
            .:|.:|:.|:|.|.|.|.::..|:.|....|       .:|.:::........:|.:.::
  Fly   174 LACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAELPQFTIIGYETND----- 233

  Fly   206 EWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSD-S 269
                      |.|:..|   ..|..::.:..::|...::.....:|.:.|..|:.:.|::..: :
  Fly   234 ----------RKERLAT---GVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEAT 285

  Fly   270 GEKVSLSISILLSLTVFFLLLAEIIPPTSLV----VPLLGKFV-LFTMILDTFSICVTVLVLNIH 329
            ..:|:|.|:.:|::|.....:...:|..|.|    :.|:..|| :|..:|:..::..|.
  Fly   286 SARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTY------ 344

  Fly   330 FRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMI-----KSSRRLMVRTCNG----LELRD 385
                       |.:..           ::.:..:.|..     ||.|.   .||:.    :||:|
  Fly   345 -----------WGKRA-----------KKKIKKVKECCPGKIGKSERS---ETCSTTEDIIELQD 384

  Fly   386 ----QIPPL----------------------PPPVALSRMHHSPKTTSR-------STSPHLQH- 416
                .||.|                      ||...::|.:.:..:..|       ||.|.:.|
  Fly   385 VRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHA 449

  Fly   417 -------------RVQTYNLMDE 426
                         :::..|::|:
  Fly   450 LKRGASAIKATIPKIKDVNIIDK 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	45/231 (19%)
		Cys-loop	150..164	CDD:349832	6/13 (46%)
		LGIC_TM_nAChR	242..>331	CDD:349866	18/94 (19%)
		TM1 helix	242..266	CDD:349866	4/23 (17%)
		TM2 helix	274..295	CDD:349866	4/20 (20%)
		TM3 helix	306..328	CDD:349866	5/22 (23%)
		Neur_chan_memb	<683..760	CDD:460753
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	86/478 (18%)