DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and chrnb3b

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_775394.1 Gene:chrnb3b / 317643 ZFINID:ZDB-GENE-030102-4 Length:462 Species:Danio rerio


Alignment Length:427 Identity:195/427 - (45%)
Similarity:263/427 - (61%) Gaps:37/427 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VTIDMILVLSFISSSTANPDAKR----------LYDDLLSNYNKLVRPVVNVTDALTVRIKLKLS 60
            :|:.:|.:.:..:|..|...|:.          |..||...|.:.|||:::....:.||..||:|
Zfish     1 MTLTVIGLFTLFTSIFATTPAREFVSLAEREDALLRDLFQGYQRWVRPILHANHTVKVRFGLKIS 65

  Fly    61 QLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT 125
            ||:||:.|||:||||:|:.:.|.||||:|.|:.|||:..:.|||:.||.||||||.||||.||.:
Zfish    66 QLVDVDEKNQLMTTNVWLYEEWLDYKLRWNPENYGGITFIRVPSESIWLPDIVLYENADGRFEGS 130

  Fly   126 LATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTN 190
            :.|||.:.|.|.:.|.|||.|||:|.:||.:||||.|.|.||||||||||..|:|         .
Zfish   131 IMTKAIVRYNGLITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVEL---------V 186

  Fly   191 VVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGI 255
            :|...||.|:|:.:.||:||.....:..:.......||  ||::..::|..||||:.|||||:|:
Zfish   187 LVNHQVDRSDFFDNGEWEILSATGHKGSRRDGHYSYPY--ITYSFILKRLPLFYTLFLIIPCLGL 249

  Fly   256 SFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSIC 320
            ||||:||||||||.|||||||.|:|:|||||.|::.||||.:|.|:||:|:::||.||..|.||.
Zfish   250 SFLTVLVFYLPSDEGEKVSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSII 314

  Fly   321 VTVLVLNIHFRSPQT-HTMAPWVRTVFINQLPRFLVMR----RPLYPISEMIKSSRRLMVRTCNG 380
            |||.|:|:|.||..| |.|:|||||:|:.:||..|.||    |..||  :|...|..|..|:..|
Zfish   315 VTVFVINVHHRSSATYHPMSPWVRTLFLQRLPDLLCMRGNTDRYHYP--QMEPQSPDLKPRSKKG 377

  Fly   381 LELRDQIPPLP--PPVALSRMHHSPKTTSRSTSPHLQ 415
                   ||.|  ...||..|......:.|..|.|::
Zfish   378 -------PPGPEGDGQALINMLEQATNSVRYISRHIK 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 99/227 (44%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 59/88 (67%)
TM1 helix 242..266 CDD:349866 18/23 (78%)
TM2 helix 274..295 CDD:349866 13/20 (65%)
TM3 helix 306..328 CDD:349866 11/21 (52%)
Neur_chan_memb <683..760 CDD:460753
chrnb3bNP_775394.1 LIC 5..449 CDD:455710 194/423 (46%)
Blue background indicates that the domain is not in the aligned region.

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