Protein Alignment nAChRalpha3 and CG6927

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 114/575 - (19%)
• Similarity: 208/575 - (36%)
• Gaps: 151/575 - (26%)

  Fly     1 MKWFQVTIDMILVLSFISSSTANPDAKRLYD-DLLS------------NYNKLVRPVV--NVTDA 50
            |:| .:.|.::|...:.|:|..:.|...|.| |.||            .|::|.||:.  .....
  Fly     1 MEW-SLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQR 64

  Fly    51 LTVRIKLKLSQLIDVNLKNQIMTTNLW--VEQSWYDYKLKW---EPKEYG---GVEMLHVPSDHI 107
            |.|.:.::.......||:...:...::  ::..:.|.:|.:   .||...   |.|.|.   :.:
  Fly    65 LPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLR---NSL 126

  Fly   108 WRPDIVLYNNADG--------NFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTC 164
            |.|.|.|.|..|.        :...:::...|:..:.|::   ..:|   |.::::.||||||.|
  Fly   127 WMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIK---ATLY---CWLNLKKFPFDEQHC 185

  Fly   165 VMKFGSW-----------------TYDGFQVDLRHIDEL----NGTNVVEVGVDLSEFYTSVEWD 208
            .....||                 ||||    ..|:.|.    :.:|...:..|||:
  Fly   186 STVLESWMYNTSELVLHWEQKRPITYDG----ALHLTEFVLQRSWSNETVINADLSD-------- 238

  Fly   209 ILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSG-EK 272
                  :|:..|    ...|..::|.:.:.|...||.::..:|.|.|..::.:.|:|.:|.. .:
  Fly   239 ------LRHGAF----AGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPR 293

  Fly   273 VSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHT 337
            ::|..|.||:.........:.:|..|           :..:.:.:.:..|:.:
  Fly   294 ITLGTSTLLTFITLASAQGKTLPKVS-----------YIKVSEVWFLGCTIFI------------ 335

  Fly   338 MAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHS 402
            ....|...|:|.:.|    |:...|:.::  :|:.::..|.:             |..|.|..|:
  Fly   336 FGSMVEFAFVNTIWR----RKKSVPVKKL--NSKHILKSTLS-------------PNLLRRRSHA 381

  Fly   403 PKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQ 467
               .|||.|....|:.        ...|..|||. ...:|:...|.|       |.....::|.|
  Fly   382 ---RSRSFSGTALHKT--------ADTGSLGGAG-FNNYLTVNLPIT-------TIKEGQVLDQQ 427

  Fly   468 YHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGH 522
            ..::..|.    :|.....:.|..|.|..| ||...:.:.:.........:|.||
  Fly   428 RTSRVVQK----MDVNFVESAFGSMGSAQS-TGAISAASSSQTLTNNNRTESAGH 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	54/266 (20%)
		Neur_chan_memb	248..>359	CDD:280999	18/111 (16%)
		Neur_chan_memb	<683..760	CDD:280999
CG6927	NP_572194.1	LIC	3..520	CDD:273305	113/573 (20%)
		Neur_chan_LBD	36..259	CDD:280998	48/253 (19%)
		Neur_chan_memb	270..518	CDD:280999	51/274 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030