Protein Alignment nAChRalpha3 and HTR3E

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001243543.1
• Gene: HTR3E / 285242
• HGNCID: 24005
• Length: 482
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 109/493 - (22%)
• Similarity: 189/493 - (38%)
• Gaps: 153/493 - (31%)

  Fly    22 ANPDAKRLYDDLLSNYN-KLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDY 85
            |:|.|      |.|.:| |..|||.|::....|.|...:|.::||               .|.:.
Human    55 ADPTA------LNSVFNRKPFRPVTNISVPTQVNISFAMSAILDV---------------VWDNP 98

  Fly    86 KLKWEPKEYGGVEMLHVPSDHIWRPDIVLY----------------NNADGN------FEVTLAT 128
            .:.|.|:|..|:..:.:.:.::|.|||.:.                ::.|.:      .:|....
Human    99 FISWNPEECEGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTP 163

  Fly   129 KATLNYT---GRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTY--DGFQVDL-RHIDELN 187
            |....|.   ||:.::.|....|.|.:|:.|||||:|.|.:.|.|:.|  |...:|: :.:.|:.
Human   164 KGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEIT 228

  Fly   188 --GTNVVEVGVDLSEFYTSVEWDILEVPAV-----RNEKFYTCCDEPYLDITFNITMRRKTLFYT 245
              ..|:::         |..||::|.:...     |....|.       .|.|.:.:||:...|.
Human   229 DASRNILQ---------THGEWELLGLSKATAKLSRGGNLYD-------QIVFYVAIRRRPSLYV 277

  Fly   246 VNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLF 310
            :||::|...:..:..|.||||..||.:|...|::||...||.|::::::|.:.  .||:|.:
Human   278 INLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVY--- 337

  Fly   311 TMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMV 375
                  |::|::::|.::             :.|:||..|                      |.|
Human   338 ------FALCLSLMVGSL-------------LETIFITHL----------------------LHV 361

  Fly   376 RTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITG 440
            .|       .|.||||..:....:|.:.......|:|..:::                |......
Human   362 AT-------TQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENK----------------GPGLTPT 403

  Fly   441 HLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGS 478
            ||..:..|.:|.........:.|           ||||
Human   404 HLPGVKEPEVSAGQMPGPAEAEL-----------TGGS 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	57/250 (23%)
		Neur_chan_memb	248..>359	CDD:280999	27/110 (25%)
		Neur_chan_memb	<683..760	CDD:280999
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	52/233 (22%)
		Neur_chan_memb	280..>379	CDD:280999	35/151 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810