DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and HTR3E

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_001243543.1 Gene:HTR3E / 285242 HGNCID:24005 Length:482 Species:Homo sapiens


Alignment Length:493 Identity:109/493 - (22%)
Similarity:189/493 - (38%) Gaps:153/493 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ANPDAKRLYDDLLSNYN-KLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDY 85
            |:|.|      |.|.:| |..|||.|::....|.|...:|.::||               .|.:.
Human    55 ADPTA------LNSVFNRKPFRPVTNISVPTQVNISFAMSAILDV---------------VWDNP 98

  Fly    86 KLKWEPKEYGGVEMLHVPSDHIWRPDIVLY----------------NNADGN------FEVTLAT 128
            .:.|.|:|..|:..:.:.:.::|.|||.:.                ::.|.:      .:|....
Human    99 FISWNPEECEGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTP 163

  Fly   129 KATLNYT---GRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTY--DGFQVDL-RHIDELN 187
            |....|.   ||:.::.|....|.|.:|:.|||||:|.|.:.|.|:.|  |...:|: :.:.|:.
Human   164 KGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEIT 228

  Fly   188 --GTNVVEVGVDLSEFYTSVEWDILEVPAV-----RNEKFYTCCDEPYLDITFNITMRRKTLFYT 245
              ..|:::         |..||::|.:...     |....|.       .|.|.:.:||:...|.
Human   229 DASRNILQ---------THGEWELLGLSKATAKLSRGGNLYD-------QIVFYVAIRRRPSLYV 277

  Fly   246 VNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLF 310
            :||::|...:..:..|.||||..||.:|...|::||...||.|::::::|.:.  .||:|.:   
Human   278 INLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVY--- 337

  Fly   311 TMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMV 375
                  |::|::::|.::             :.|:||..|                      |.|
Human   338 ------FALCLSLMVGSL-------------LETIFITHL----------------------LHV 361

  Fly   376 RTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITG 440
            .|       .|.||||..:....:|.:.......|:|..:::                |......
Human   362 AT-------TQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENK----------------GPGLTPT 403

  Fly   441 HLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGS 478
            ||..:..|.:|.........:.|           ||||
Human   404 HLPGVKEPEVSAGQMPGPAEAEL-----------TGGS 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 57/253 (23%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 25/88 (28%)
TM1 helix 242..266 CDD:349866 7/23 (30%)
TM2 helix 274..295 CDD:349866 6/20 (30%)
TM3 helix 306..328 CDD:349866 3/21 (14%)
Neur_chan_memb <683..760 CDD:460753
HTR3ENP_001243543.1 LGIC_ECD 46..272 CDD:475126 58/253 (23%)
LIC 70..480 CDD:455710 102/472 (22%)
Blue background indicates that the domain is not in the aligned region.

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