DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and Chrng

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_062018.1 Gene:Chrng / 25753 RGDID:2354 Length:519 Species:Rattus norvegicus


Alignment Length:457 Identity:155/457 - (33%)
Similarity:249/457 - (54%) Gaps:58/457 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            ::|:|:....:.:....:||..||:.||:..:||....:|.:.|.:||.|:.||.:|.:.:.:||
  Rat    10 LLLLLATCLGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTT 74

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139
            |:|:|..|.||:|:|:||:|.|:.:|.|||..:|:|||||.||.||.|||.|.....::..|.:.
  Rat    75 NVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWQPDIVLGNNVDGVFEVALYCNVLVSPDGCIY 139

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTS 204
            |.||||::|||.|.|.|||||.|.|.:.|.|.||...:::|: :.:.:|..:..:.:|...|..:
  Rat   140 WLPPAIFRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQ-LSQEDGQAIEWIFIDPEAFTEN 203

  Fly   205 VEWDILEVPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSD 268
            .||.|...||.......|..:|. :..:.|.:.::||.|||.:|:|:||:.||.:.||:::||:.
  Rat   204 GEWAIRHRPAKMLLDPVTPAEEAGHQKVVFYLLIQRKPLFYVINIIVPCVLISSVAILIYFLPAK 268

  Fly   269 S-GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRS 332
            : |:|.:::.::||:.|||..|:|:.:|.||..|||:.|::.|.|::....:..:|:|||:..||
  Rat   269 AGGQKCTVATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRS 333

  Fly   333 PQTHTMAPWVRTVFINQLPRFLVM----RRPL----------------YPI------------SE 365
            |.||:||..||.||:..||:.|.|    |.|.                :||            ||
  Rat   334 PHTHSMARGVRKVFLRLLPQLLRMHVHPRAPAAVQDARLRLQNGSSSGWPIMTREEGDLCLPRSE 398

  Fly   366 MIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKT--------TSRSTSPHLQHRVQTYN 422
            ::...|:.     |||          ....|.::.:.|:.        :.:..||.:|..|...|
  Rat   399 LLFRQRQR-----NGL----------VQAVLEKLENGPEMRQSQEFCGSLKQASPAIQACVDACN 448

  Fly   423 LM 424
            ||
  Rat   449 LM 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 84/218 (39%)
Cys-loop 150..164 CDD:349832 9/13 (69%)
LGIC_TM_nAChR 242..>331 CDD:349866 35/89 (39%)
TM1 helix 242..266 CDD:349866 11/23 (48%)
TM2 helix 274..295 CDD:349866 7/20 (35%)
TM3 helix 306..328 CDD:349866 6/21 (29%)
Neur_chan_memb <683..760 CDD:460753
ChrngNP_062018.1 LGIC_ECD_nAChR_G 49..241 CDD:349830 75/192 (39%)
Cys-loop 150..164 CDD:349830 9/13 (69%)
Neur_chan_memb 248..494 CDD:460753 65/218 (30%)
Blue background indicates that the domain is not in the aligned region.

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