DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and Chrnb4

DIOPT Version :9

Sequence 1:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_434693.1 Gene:Chrnb4 / 25103 RGDID:2351 Length:495 Species:Rattus norvegicus


Alignment Length:773 Identity:234/773 - (30%)
Similarity:335/773 - (43%) Gaps:297/773 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ILVLSFIS------SSTANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            :|::|..|      ...||.:.| |.||||  :.||.|:||..:.:..:::|::|.|||||.||.
  Rat     6 LLLVSLFSLLQDGDCRLANAEEK-LMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNE 69

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            :.|||||::|::|.|.||:|.|....|.||.:|.:|:..:|.|||||||||||.:||::.|...:
  Rat    70 REQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIV 134

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            ...|.::|.|||||||:|:|:|::||||:|.|.:||.|||||..::|:    .|.....:     
  Rat   135 RSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDM----VLKSPTAI----- 190

  Fly   198 LSEFYTSVEWDILEVPAVR--NEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
            :.:|..|.||||:.:|..|  |.:     |..|:|:|::..::||.||||:||||||:.|:.|.|
  Rat   191 MDDFTPSGEWDIVALPGRRTVNPQ-----DPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAI 250

  Fly   261 LVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLV 325
            ||||||||.|||::|.||:||:||.|.||:::|:|||||.:||:||::||||:|.||||..||.|
  Rat   251 LVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCV 315

  Fly   326 LNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPL 390
            ||:|.|||.|||||.||:..|:::||.||.|:||                    |||        
  Rat   316 LNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRP--------------------GLE-------- 352

  Fly   391 PPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQ 455
               |:|.|:.|                                             |..:..|..
  Rat   353 ---VSLVRVPH---------------------------------------------PSQLHLATA 369

  Fly   456 QTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSG 520
            .|:.||:|                  .|.:|:..                       ||      
  Rat   370 DTAATSAL------------------GPTSPSNL-----------------------YG------ 387

  Fly   521 GHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGT 585
                                           |.:...||                          
  Rat   388 -------------------------------SSMYFVNP-------------------------- 395

  Fly   586 IQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPST 650
                                                                            .
  Rat   396 ----------------------------------------------------------------V 396

  Fly   651 SAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVT 715
            .||..:|.::..||.|                 |:..   ....|..|:      :|.:|::||:
  Rat   397 PAAPKSAVSSHTAGLP-----------------RDAR---LRSSGRFRE------DLQEALEGVS 435

  Fly   716 YIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMP 773
            :||.....::....|.||||:||||:||||||:|....::||.|:.|  |.|:....|
  Rat   436 FIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFL--PPLFQIHAP 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 93/218 (43%)
Neur_chan_memb 248..>359 CDD:280999 70/110 (64%)
Neur_chan_memb <683..760 CDD:280999 27/76 (36%)
Chrnb4NP_434693.1 LIC 21..483 CDD:273305 228/748 (30%)
LGIC_ECD 53..230 CDD:355788 81/190 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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