DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and Chrna5

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_058774.2 Gene:Chrna5 / 25102 RGDID:2347 Length:467 Species:Rattus norvegicus


Alignment Length:342 Identity:172/342 - (50%)
Similarity:243/342 - (71%) Gaps:15/342 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 ISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQS 81
            :||:..:.|:  |:.||..:|.:.||||.:::|.:.::..|.:|||:||:.|||:||||:|::|.
  Rat    40 LSSAAKHEDS--LFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQE 102

  Fly    82 WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIY 146
            |.|.||:|.|.:|||::::.||||.:|.|||||::||||.|| ..:||..:.|.|.|.|..||.|
  Rat   103 WIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFE-GASTKTVVRYNGTVTWTQPANY 166

  Fly   147 KSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILE 211
            ||||.|||.:||||.|.|.||||||||||.|||:...|:         .||.::|:.:.||:|:.
  Rat   167 KSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDRTDFFDNGEWEIMS 222

  Fly   212 VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLS 276
            ....:..:..:||..||  ||::..::|..||||:.|||||:|:||||::||||||:.|||:||.
  Rat   223 AMGSKGNRTDSCCWYPY--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLC 285

  Fly   277 ISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTH-TMAP 340
            .|:|:|||||.|::.||||.:|.|:||:|::::||||..|.||.|||..:|||.||..|| .|||
  Rat   286 TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAP 350

  Fly   341 WVRTVFINQLPRFLVMR 357
            |||.:|:::||:.|.||
  Rat   351 WVRKIFLHKLPKLLCMR 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 99/217 (46%)
Cys-loop 150..164 CDD:349832 9/13 (69%)
LGIC_TM_nAChR 242..>331 CDD:349866 55/88 (63%)
TM1 helix 242..266 CDD:349866 17/23 (74%)
TM2 helix 274..295 CDD:349866 12/20 (60%)
TM3 helix 306..328 CDD:349866 10/21 (48%)
Neur_chan_memb <683..760 CDD:460753
Chrna5NP_058774.2 LGIC_ECD 45..251 CDD:475126 99/219 (45%)
Neur_chan_memb 257..446 CDD:460753 67/111 (60%)
Blue background indicates that the domain is not in the aligned region.

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