DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and Chrnb1

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001382047.1	Gene:	Chrnb1 / 24261	RGDID:	2349	Length:	504	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	207/772 - (26%)
Similarity:	308/772 - (39%)	Gaps:	301/772 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MILVLSFISSSTANPDAK------RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDV--- 65
            ::|:|..:.:..| |.|:      :|...|.|:|:..|||...|.|.:.|.|.|.|:|||.:
  Rat     6 LLLILGILGTPLA-PGARGSEAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLVRE 69

  Fly    66 NLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKA 130
            |.|::.|:|.::::..|.||:|.|:|.|:.|:|.|.|.::.:|.||:||.||.||||:|.|....
  Rat    70 NEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNNDGNFDVALDINV 134

  Fly   131 TLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG 195
            .:::.|.|.|:||.:|:|||.|.|.|||||.|.|.|.|.|::||..:|.|:...:.:|....|:.
  Rat   135 VVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQEIY 199

  Fly   196 VDLSEFYTSVEWDILEVPA--------VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPC 252
            :....|..:.:|:|:..|:        .|..|     :....::.|.:.:|||.|||.||:|.||
  Rat   200 IHEGTFIENGQWEIIHKPSRLIHLPGDRRGGK-----EGHREEVIFYLIIRRKPLFYLVNVIAPC 259

  Fly   253 MGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTF 317
            :.|:.|.|.|||||.|:|||:.|||..||:||||.||||:.:|.|||.||::.|:::|||||.||
  Rat   260 ILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILVTF 324

  Fly   318 SICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLE 382
            |:.::|:|||:|.|||.||.|..|||.:||::||.:|.::||        |..
  Rat   325 SVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRP--------KPE------------ 369

  Fly   383 LRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYP 447
             |||:|                      .||
  Rat   370 -RDQLP----------------------EPH---------------------------------- 377

  Fly   448 PTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGG 512
                                              |..:|.                ||.|.|...
  Rat   378 ----------------------------------HSFSPR----------------SGWGRGTDE 392

  Fly   513 YGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTL 577
            |           :.::..|...|..|.:...::.|           |::.:             .
  Rat   393 Y-----------FIRKPPCDFLFPKLNRFQPESPA-----------PDLRR-------------F 422

  Fly   578 ADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAA 642
            .|.
  Rat   423 IDG-------------------------------------------------------------- 425

  Fly   643 AAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPEL 707
                                      ||...|    ||                        .||
  Rat   426 --------------------------PPRAVG----LP------------------------QEL 436

  Fly   708 HKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQA 764
            .:.:..::|:|.|.:::|:...:||||::||||:||||||.|.:...|||..|.|.|
  Rat   437 REVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDA 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	81/231 (35%)
		Neur_chan_memb	248..>359	CDD:280999	62/110 (56%)
		Neur_chan_memb	<683..760	CDD:280999	24/76 (32%)
Chrnb1	NP_001382047.1	LGIC_ECD_nAChR_B1	27..248	CDD:349825	80/225 (36%)
		Neur_chan_memb	255..490	CDD:397193	113/512 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..384		11/145 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810