DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and pbo-6

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001294833.1	Gene:	pbo-6 / 24104421	WormBaseID:	WBGene00017375	Length:	422	Species:	Caenorhabditis elegans

Alignment Length:	353	Identity:	95/353 - (26%)
Similarity:	175/353 - (49%)	Gaps:	32/353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILVLSFISSSTA---------NPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVN 66
            :.:..||::.|.         ...:.||...||..:||...|    ...:.:...::|..:|.:|
Worm     6 LTIFIFITTVTVGVAEFSEQYQGSSSRLTRHLLEKHNKCSPP----DGRVDISHNIELVHIIGIN 66

  Fly    67 LKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEV-TLATKA 130
            ..||.|...:::.|.|.|..|.|:.:|:.|::...:|...||.|||:::|..:....: .:.:..
Worm    67 ELNQNMQVLVYIVQQWTDASLSWKVEEFRGIKHTWLPEHSIWIPDIIVFNTLEHKMLLEAVRSPI 131

  Fly   131 TLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG 195
            .::|||.|.:..||||...|:|.:..||||:|.|.::|.||.||..::      .||.::...
Worm   132 KVSYTGEVTYAYPAIYTVLCQIGIATFPFDDQVCKIRFASWAYDEDKI------LLNASHKPL-- 188

  Fly   196 VDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
              |..:..:.||.:.:|...|.|  |...:....:|.:.|.:.||..:|.::|::|...|..|:|
Worm   189 --LKNYSPNEEWALQDVDMARKE--YEHEETVVSEIIYYIKVARKPFYYLISLVVPSYIICVLSI 249

  Fly   261 ----LVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICV 321
                ..|....:..|:.:|.::.:||:.|..|::.|.:|.:|..||||..::.|.:::.|.:..:
Worm   250 AGLFARFSTKHERQERFTLGVTAILSMAVLSLVVTEKVPHSSENVPLLIVYMHFIIVMVTIATIL 314

  Fly   322 TVLVLNIHFRSPQTHTMAP--WVRTVFI 347
            |..|:.:|.:..:||.::|  |:|.|.:
Worm   315 TSTVMRVHAKGFRTHFLSPPNWIRKVLL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	60/215 (28%)
		Neur_chan_memb	248..>359	CDD:280999	30/106 (28%)
		Neur_chan_memb	<683..760	CDD:280999
pbo-6	NP_001294833.1	Neur_chan_LBD	31..230	CDD:280998	60/214 (28%)
pbo-6	NP_001294833.1	Neur_chan_memb	264..>342	CDD:280999	24/77 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810