DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and Chrna9

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001074573.1	Gene:	Chrna9 / 231252	MGIID:	1202403	Length:	479	Species:	Mus musculus

Alignment Length:	352	Identity:	158/352 - (44%)
Similarity:	226/352 - (64%)	Gaps:	15/352 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TANPD-AKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 84
            |||.. |::|:.||..:|:..:|||.:....|.|.:::.|||:.|::.:|||:|..||:.|:|:|
Mouse    25 TANGKYAQKLFSDLFEDYSNALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHD 89

  Fly    85 YKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSS 149
            ..|.|:..:|.|::.:.:|||.:|||||||||.||......:.|...|.|.|.:.|..|||.|||
Mouse    90 AYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSS 154

  Fly   150 CEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPA 214
            |.:||.|||||.|.|.:.||||||:|.|||:        .|.::.| |||:|...|||::..:||
Mouse   155 CVVDVTYFPFDSQQCNLTFGSWTYNGNQVDI--------FNALDSG-DLSDFIEDVEWEVQGMPA 210

  Fly   215 VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISI 279
            |:|...|.||.|||.|:||.:.::|::.||.|||:|||:.||||..|.||||:.|||||||.::|
Mouse   211 VKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTI 275

  Fly   280 LLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRT 344
            ||::|||.|::|||: |.|..|||:||:.:.||.|.|.|..:|::|:||||...:...:..|.:.
Mouse   276 LLAMTVFQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKV 339

  Fly   345 VFINQLPRFLVMRRPLYPISEMIKSSR 371
            |.:..:.|.|.    :|.:.|...|.|
Mouse   340 VILKYMSRILF----VYDVGESCLSPR 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	95/214 (44%)
		Neur_chan_memb	248..>359	CDD:280999	52/110 (47%)
		Neur_chan_memb	<683..760	CDD:280999
Chrna9	NP_001074573.1	LIC	10..474	CDD:273305	158/352 (45%)
		Neur_chan_LBD	31..236	CDD:280998	94/213 (44%)
		Neur_chan_memb	244..474	CDD:280999	56/124 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810