DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and HTR3D

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001157118.1	Gene:	HTR3D / 200909	HGNCID:	24004	Length:	454	Species:	Homo sapiens

Alignment Length:	363	Identity:	83/363 - (22%)
Similarity:	149/363 - (41%)	Gaps:	80/363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVP 103
            |.:.||.|.:.|..|.|...||.:  .|..::|.|.|....:.|::..::|.|.|.||::...:.
Human    51 KAIGPVTNYSVATHVNISFTLSAI--WNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMA 113

  Fly   104 SDHIWRPDIVLYNNAD----GNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTC 164
            ::::|..|:.:..:.|    |........|||.|...:..|...|.:..|....::
Human   114 TENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMD--------- 169

  Fly   165 VMKFGSW--TYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEP 227
              :..:|  ....||:..|                 :.|.|..||.:|.:.. |..| .|.....
Human   170 --RARAWRRMSRSFQIHHR-----------------TSFRTRREWVLLGIQK-RTIK-VTVATNQ 213

  Fly   228 YLDITFNITMRR--KTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLL 290
            |....|::.:||  :...|.||.::|...:..:..|.||||.:||......:::||..:||.|::
Human   214 YEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMM 278

  Fly   291 AEIIPPT------SLVVPLLGKFVLFTMILDT-------FSICVTVLVLNIHFRSPQTHTMAPWV 342
            .:::|.|      |||.||        .::.|       |::|::::|.::             :
Human   279 NDLLPATSTSSHASLVAPL--------ALMQTPLPAGVYFALCLSLMVGSL-------------L 322

  Fly   343 RTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNG 380
            .|:||..| ..:...:|| |:...:.|    ::..|.|
Human   323 ETIFITHL-LHVATTQPL-PLPRWLHS----LLLHCTG 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	46/209 (22%)
		Neur_chan_memb	248..>359	CDD:280999	28/123 (23%)
		Neur_chan_memb	<683..760	CDD:280999
HTR3D	NP_001157118.1	Neur_chan_LBD	55..>130	CDD:280998	20/76 (26%)
		LIC	92..452	CDD:273305	70/320 (22%)
		Neur_chan_memb	237..>351	CDD:280999	32/140 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810