DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and HTR3D

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:XP_054201603.1 Gene:HTR3D / 200909 HGNCID:24004 Length:456 Species:Homo sapiens


Alignment Length:372 Identity:81/372 - (21%)
Similarity:150/372 - (40%) Gaps:96/372 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 KLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVP 103
            |.:.||.|.:.|..|.|...||.:  .|..::|.|.|....:.|::..::|.|.|.||::...:.
Human    51 KAIGPVTNYSVATHVNISFTLSAI--WNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMA 113

  Fly   104 SDHIWRPDIVLYNNAD-------GNFEVTLATKATLNYTG---RVEWRP---PAIYKSSCEIDVE 155
            ::::|..|:.:..:.|       .:..:..||..|::..|   ...|.|   |::.::...    
Human   114 TENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRAEPR---- 174

  Fly   156 YFPFDEQTCVMKFGSW--TYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNE 218
                          :|  ....||:..|                 :.|.|..||.:|.:.. |..
Human   175 --------------AWRRMSRSFQIHHR-----------------TSFRTRREWVLLGIQK-RTI 207

  Fly   219 KFYTCCDEPYLDITFNITMRR--KTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILL 281
            | .|.....|....|::.:|.  :...|.||.::|...:..:..|.||||.:||......:::||
Human   208 K-VTVATNQYEQAIFHVAIRHRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLL 271

  Fly   282 SLTVFFLLLAEIIPPT------SLVVPLLGKFVLFTMILDT-------FSICVTVLVLNIHFRSP 333
            ..:||.|::.:::|.|      |||.||        .::.|       |::|::::|.::     
Human   272 GYSVFLLMMNDLLPATSTSSHASLVAPL--------ALMQTPLPAGVYFALCLSLMVGSL----- 323

  Fly   334 QTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNG 380
                    :.|:||..| ..:...:|| |:...:.|    ::..|.|
Human   324 --------LETIFITHL-LHVATTQPL-PLPRWLHS----LLLHCTG 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 44/220 (20%)
Cys-loop 150..164 CDD:349832 0/13 (0%)
LGIC_TM_nAChR 242..>331 CDD:349866 27/101 (27%)
TM1 helix 242..266 CDD:349866 7/23 (30%)
TM2 helix 274..295 CDD:349866 5/20 (25%)
TM3 helix 306..328 CDD:349866 4/28 (14%)
Neur_chan_memb <683..760 CDD:460753
HTR3DXP_054201603.1 LGIC_ECD 30..228 CDD:475126 44/215 (20%)
LGIC_TM_5-HT3 232..455 CDD:349865 37/152 (24%)
TM1 helix 232..256 CDD:349865 7/23 (30%)
TM2 helix 264..285 CDD:349865 5/20 (25%)
TM3 helix 310..332 CDD:349865 6/34 (18%)
TM4 helix 430..452 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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