Protein Alignment nAChRalpha3 and acr-19

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001129756.1
• Gene: acr-19 / 191605
• WormBaseID: WBGene00000058
• Length: 560
• Species: Caenorhabditis elegans
• Alignment Length: 762
• Identity: 204/762 - (26%)
• Similarity: 320/762 - (41%)
• Gaps: 254/762 - (33%)

  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            :|||..|..|||||.|||.|.::|:.|.:.:...|::|::.|:|||.:|:|:..||.|:.|.|:|
 Worm    32 RRLYAKLAENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDP 96

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEY 156
            .|:|.::.:.:|.::||:||::|||:.|..|:.|....|.:.|||.|.|.||||.:|||.||:.|
 Worm    97 SEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAY 161

  Fly   157 FPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFY 221
            ||||.|.|.||||||||.||..||     :|.|      :..:.:..:.||::|.:.:.|:..||
 Worm   162 FPFDTQHCTMKFGSWTYSGFFTDL-----INTT------ISPATYKPNGEWELLGLTSQRSIFFY 215

  Fly   222 TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVF 286
            .||.|||.|:||.:::||:||:|..||::|||.||.|.:|.|.||:|.|||::|.::|.:||.||
 Worm   216 ECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLNLGVTIFMSLCVF 280

  Fly   287 FLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTH-TMAPWVRTVFINQL 350
            .:::||.:|.||..:||:..:....|.....|:..||:.||.|.|||:.: .|..:::|:.:..|
 Worm   281 MIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPMNKFLKTLLLGWL 345

  Fly   351 PRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQ 415
            |..|.|.||                   :.|||                           |.|
 Worm   346 PTLLGMERP-------------------DVLEL---------------------------SVH-- 362

  Fly   416 HRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLL 480
                              ||     |.:|         :.:......||:.:.|         :|
 Worm   363 ------------------GA-----HYAS---------DNKKKQRQYLIEVERH---------IL 386

  Fly   481 DHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHG----------QSGGHHLYRQQSSCSANF 535
            ..|                        |||    ||.          .:|..|...::|
 Worm   387 TRP------------------------NGN----GHSAVDKAVHLDLSTGNPHSDAKKS------ 417

  Fly   536 SPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQS 600
            ||.|:.       |:.|.:||..    ..||.:|....:|....:|...|..:..|
 Worm   418 SPSPKR-------TSASIMGMTG----LPTTQMNGALDSSINKYTCTKVTRPLENG--------- 462

  Fly   601 SELLHHQQ------LHHQQMH---HQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAA 656
            |..::|:.      :::..::   :.|:.|.:.:|.||
 Worm   463 SATINHKSSPQINPINNNNIYKCANNQKTQFEDRHFHH--------------------------- 500

  Fly   657 AAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQT 721
                                                                 .::.:..|:.:.
 Worm   501 -----------------------------------------------------ILNELRVISARV 512

  Fly   722 RKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLY 768
            ||||....::.||.:.:.|:||:....|:..:.:.||.|...||.|:
 Worm   513 RKEEAMHALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLF 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	95/215 (44%)
		Cys-loop	150..164	CDD:349832	9/13 (69%)
		LGIC_TM_nAChR	242..>331	CDD:349866	38/88 (43%)
		TM1 helix	242..266	CDD:349866	12/23 (52%)
		TM2 helix	274..295	CDD:349866	8/20 (40%)
		TM3 helix	306..328	CDD:349866	5/21 (24%)
		Neur_chan_memb	<683..760	CDD:460753	13/76 (17%)
acr-19	NP_001129756.1	LIC	31..548	CDD:455710	198/749 (26%)
		LGIC_ECD_nAChR	56..234	CDD:349798	79/188 (42%)
		Cys-loop	155..169	CDD:349798	9/13 (69%)