Protein Alignment nAChRalpha3 and acr-18

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_506868.2
• Gene: acr-18 / 191604
• WormBaseID: WBGene00000057
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 135/476 - (28%)
• Similarity: 227/476 - (47%)
• Gaps: 89/476 - (18%)

  Fly    18 SSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSW 82
            :|..|....:.||:.|..:|.|.:|||.|.:::|.|.||..|.|::.|:.::||:....|:|..|
 Worm    22 TSHPARTPMRNLYEHLFLDYVKEIRPVRNESESLKVEIKFWLKQILKVDERDQIVNIYCWLELYW 86

  Fly    83 YDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT-LATKATLNYTGRVEWRPPAIY 146
            .|..|.|:||::|.:..:|||:..||:||:::||||:.|.|.. :.|.|.::.||||......|.
 Worm    87 IDETLTWDPKKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETNAIVDNTGRVMLFRSMIT 151

  Fly   147 KSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILE 211
            ..||.::::.||||:|.|.:.|.||:.||.::||....:.:         :|..:..:.||.:.:
 Worm   152 DISCNLNLQQFPFDQQICFVTFASWSMDGSKLDLSATPKTD---------NLELYIRNTEWGLTD 207

  Fly   212 VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLP----SDSGEK 272
            ......:|.|.||..|:.|:|:.:.:||...:|..:|:||...|:.:||:.|:.|    .::.||
 Worm   208 FRVKIYQKIYDCCPHPFPDVTYFMVLRRSPSYYIFSLVIPSAFITVVTIVGFFTPHSTTGENTEK 272

  Fly   273 VSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHT 337
            |||.::.|||:.:..:::::.:|.||.|:||:||:.:..:.|...:...|.|.|:...|......
 Worm   273 VSLGVTALLSMAIIMMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAAFTTTLTLSYQMRGNSGQE 337

  Fly   338 MAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHS 402
            :.|.||..|..|:                          ..|            |.::.:.....
 Worm   338 VDPRVRDFFFYQI--------------------------AAN------------PCISWAFSFQL 364

  Fly   403 PKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGH-LSSLYPPT----------------- 449
            ||...||     .||.|::...:        ||:.:.|: ..:|:|.|
 Worm   365 PKKLLRS-----DHRKQSFFFTN--------GAAHVNGYSKGALHPNTPPAHIVKMEEITGGGSV 416

  Fly   450 ----MSTANQQTST--TSSLI 464
                ||..:..|||  ||||:
 Worm   417 KSFVMSQESAATSTLLTSSLM 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	74/215 (34%)
		Neur_chan_memb	248..>359	CDD:280999	34/114 (30%)
		Neur_chan_memb	<683..760	CDD:280999
acr-18	NP_506868.2	Neur_chan_LBD	33..237	CDD:280998	74/212 (35%)
		Neur_chan_memb	244..486	CDD:280999	58/245 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810