Protein Alignment nAChRalpha3 and lev-8

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_509932.2
• Gene: lev-8 / 191600
• WormBaseID: WBGene00002975
• Length: 531
• Species: Caenorhabditis elegans
• Alignment Length: 497
• Identity: 176/497 - (35%)
• Similarity: 280/497 - (56%)
• Gaps: 76/497 - (15%)

  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            :::.:..|.:..||....:|.::||::|||.||||.|.:|||.|:....|.:||||:..||::||
 Worm    13 LVIFILHIVTINANKHVSQLLENLLTDYNKAVRPVHNASDALKVKFGANLCRLIDVDEVNQVLTT 77

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139
            :||:|..|||.||.|.|.::||||.:|:|||.||.|||||||||||...:|:.:.|.:::.|||.
 Worm    78 SLWLEMQWYDKKLTWNPTDWGGVEYIHIPSDQIWIPDIVLYNNADGEPHITITSLAKIDHHGRVV 142

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHI----DEL-------NGTN--V 191
            |:||:||||.|.|:::|||:|.|||.||||.|:.||..:||..|    |::       :|..  .
 Worm   143 WQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQIPVDVDDIPQVKRQDDGVEFLY 207

  Fly   192 VEVGVDLSEFYTSVEWDILEVPAVRNEKFYT-CCDEP-YLDITFNITMRRKTLFYTVNLIIPCMG 254
            :|.|:.||.::.|.|||:|...:.|..:.|. ||.:. |:||.:.|.:|||.:|:||.|.||||.
 Worm   208 LEKGLGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRIIIRRKAIFFTVTLTIPCML 272

  Fly   255 ISFLTILVF-YLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFS 318
            |:.:|..|| .||::  .|::.|||:|::.:||:|:|.::||||||.:.|:|.::|||:::.:.|
 Worm   273 IANVTPFVFLILPNE--HKMTYSISVLVAFSVFYLVLIDLIPPTSLSLSLIGIYLLFTLLMVSVS 335

  Fly   319 ICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMR------------RPLYPISEMIKSSR 371
            |.::|:.:|::.:...:..|:.|.|.:|:.:||:.|.::            ....|.:..:..:.
 Worm   336 IILSVVTINMYRKQAFSSGMSHWQRWLFVQRLPKLLRLKTLEHTLGPDEGSETTTPRTGSVSVTA 400

  Fly   372 RLMVRTCNGLELRDQIPPLPPP----VALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMG 432
            .:..||.|.   .:..|..||.    ::|.:|..:.|....:.:..|..:
 Worm   401 SVTQRTLNP---NNNSPVFPPQRLRLLSLVQMDEALKQRCAADNLDLFRK--------------- 447

  Fly   433 GGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQ 474
                 |.|||                   .:|.|.:|||..:
 Worm   448 -----IAGHL-------------------KIISAHFHNQQME 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	108/232 (47%)
		Cys-loop	150..164	CDD:349832	7/13 (54%)
		LGIC_TM_nAChR	242..>331	CDD:349866	38/89 (43%)
		TM1 helix	242..266	CDD:349866	12/24 (50%)
		TM2 helix	274..295	CDD:349866	8/20 (40%)
		TM3 helix	306..328	CDD:349866	6/21 (29%)
		Neur_chan_memb	<683..760	CDD:460753
lev-8	NP_509932.2	LIC	10..499	CDD:455710	176/497 (35%)
		LGIC_ECD	31..261	CDD:475126	108/229 (47%)