Protein Alignment nAChRalpha3 and lev-8

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_509932.2
• Gene: lev-8 / 191600
• WormBaseID: WBGene00002975
• Length: 531
• Species: Caenorhabditis elegans
• Alignment Length: 497
• Identity: 176/497 - (35%)
• Similarity: 280/497 - (56%)
• Gaps: 76/497 - (15%)

  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            :::.:..|.:..||....:|.::||::|||.||||.|.:|||.|:....|.:||||:..||::||
 Worm    13 LVIFILHIVTINANKHVSQLLENLLTDYNKAVRPVHNASDALKVKFGANLCRLIDVDEVNQVLTT 77

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139
            :||:|..|||.||.|.|.::||||.:|:|||.||.|||||||||||...:|:.:.|.:::.|||.
 Worm    78 SLWLEMQWYDKKLTWNPTDWGGVEYIHIPSDQIWIPDIVLYNNADGEPHITITSLAKIDHHGRVV 142

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHI----DEL-------NGTN--V 191
            |:||:||||.|.|:::|||:|.|||.||||.|:.||..:||..|    |::       :|..  .
 Worm   143 WQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQIPVDVDDIPQVKRQDDGVEFLY 207

  Fly   192 VEVGVDLSEFYTSVEWDILEVPAVRNEKFYT-CCDEP-YLDITFNITMRRKTLFYTVNLIIPCMG 254
            :|.|:.||.::.|.|||:|...:.|..:.|. ||.:. |:||.:.|.:|||.:|:||.|.||||.
 Worm   208 LEKGLGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRIIIRRKAIFFTVTLTIPCML 272

  Fly   255 ISFLTILVF-YLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFS 318
            |:.:|..|| .||::  .|::.|||:|::.:||:|:|.::||||||.:.|:|.::|||:::.:.|
 Worm   273 IANVTPFVFLILPNE--HKMTYSISVLVAFSVFYLVLIDLIPPTSLSLSLIGIYLLFTLLMVSVS 335

  Fly   319 ICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMR------------RPLYPISEMIKSSR 371
            |.::|:.:|::.:...:..|:.|.|.:|:.:||:.|.::            ....|.:..:..:.
 Worm   336 IILSVVTINMYRKQAFSSGMSHWQRWLFVQRLPKLLRLKTLEHTLGPDEGSETTTPRTGSVSVTA 400

  Fly   372 RLMVRTCNGLELRDQIPPLPPP----VALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMG 432
            .:..||.|.   .:..|..||.    ::|.:|..:.|....:.:..|..:
 Worm   401 SVTQRTLNP---NNNSPVFPPQRLRLLSLVQMDEALKQRCAADNLDLFRK--------------- 447

  Fly   433 GGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQ 474
                 |.|||                   .:|.|.:|||..:
 Worm   448 -----IAGHL-------------------KIISAHFHNQQME 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	107/229 (47%)
		Neur_chan_memb	248..>359	CDD:280999	42/123 (34%)
		Neur_chan_memb	<683..760	CDD:280999
lev-8	NP_509932.2	LIC	10..499	CDD:273305	176/497 (35%)
		Neur_chan_LBD	30..258	CDD:280998	106/227 (47%)
		Neur_chan_memb	268..497	CDD:280999	61/242 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870