DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and acr-10

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_508692.3 Gene:acr-10 / 191598 WormBaseID:WBGene00000049 Length:557 Species:Caenorhabditis elegans


Alignment Length:446 Identity:157/446 - (35%)
Similarity:246/446 - (55%) Gaps:43/446 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKWFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDV 65
            :::|.:.:..||.|..|.|..:..:.| ||.|:|..|.||.|||....:.|.|.:|:.|.|::::
 Worm     3 IRFFVLCLFFILSLIIIESECSKAENK-LYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNL 66

  Fly    66 NLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVP--SDHIWRPDIVLYNNADGNFEVTLAT 128
            :.:|||:..|.|::..|.||:|:|:|.:|..:..:...  .:.||||||:|||:|..:|:.:..:
 Worm    67 DGQNQIIEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKS 131

  Fly   129 KATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVE 193
            ...:..||.|.|.||.|:::||::|:.|||||:|.|.:|||||||.|..:||..|.|.:.:   |
 Worm   132 NEVVYNTGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDS---E 193

  Fly   194 VGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFL 258
            :.:|||.:..|.||.:.:.|||::.|:.:||.|||..:||.:.:||:||||..|:|:|.:.||.:
 Worm   194 LSIDLSTYTPSGEWHLTKAPAVKDVKYNSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIM 258

  Fly   259 TILVFYLPS-DSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVT 322
            |::.|.||: |..||:....:||||:..|..:::|:.||||..|||||.|.....::.:.|...|
 Worm   259 TLMGFCLPAHDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFT 323

  Fly   323 VLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQ- 386
            :.|||..:|..|...|.|....||:..:|..|:|:||     .:....||..|:....:...|. 
 Worm   324 ITVLNFRYRQVQNIHMHPIFYKVFLIWIPWLLLMKRP-----GVFYKKRRATVQAREEISFFDNG 383

  Fly   387 ------------------------IPPLPPPVALSRMHHSPKTTSRSTSPHLQHRV 418
                                    :||.|.|: |.:||..|     :...||..:|
 Worm   384 DDDCCPKPPEFDYSLSIDSADTLPLPPRPKPL-LKKMHSVP-----AEHLHLDRKV 433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 89/219 (41%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 36/89 (40%)
TM1 helix 242..266 CDD:349866 10/23 (43%)
TM2 helix 274..295 CDD:349866 6/20 (30%)
TM3 helix 306..328 CDD:349866 5/21 (24%)
Neur_chan_memb <683..760 CDD:460753
acr-10NP_508692.3 LGIC_ECD_nAChR 52..240 CDD:349798 76/190 (40%)
Cys-loop 153..167 CDD:349798 8/13 (62%)
LGIC_TM_cation 242..>332 CDD:349853 36/89 (40%)
TM1 helix 242..266 CDD:349853 10/23 (43%)
TM2 helix 275..296 CDD:349853 6/20 (30%)
TM3 helix 307..329 CDD:349853 5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

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