Protein Alignment nAChRalpha3 and acr-5

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 134/480 - (27%)
• Similarity: 218/480 - (45%)
• Gaps: 79/480 - (16%)

  Fly    25 DAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 87
            |.:||.::||  :.|.|.|.|..:.|....|.:.:.|.|::||:...|.:..|:|:.|.|||..|
 Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly    88 KWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTG---------RVEWRPP 143
            .|.|.:||.:....||...||.||..|||:.:...:.|.:.......||         :|:...|
 Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQKKDGAKVQLMFP 232

  Fly   144 AIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWD 208
            ||||.||.:||.:||:|.|.|.....|||:|...:|..   .|:.|      |:|.....:.||:
 Worm   233 AIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYW---PLSST------VNLGNMARNDEWE 288

  Fly   209 ILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSG--- 270
            ::....||.|:.:.||..|::.:..::.:|||.|:|.:||::|...|:.:.:..|:.|:.|.
 Worm   289 VISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSER 353

  Fly   271 -EKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKF---VLFTMILDTFSICVTVLVLNIHFR 331
             ||:.|.|:.||:::|..|::...:|.||..|||:..:   ::..:::.||   :...||.||.:
 Worm   354 DEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTF---LATGVLAIHGQ 415

  Fly   332 SPQTHTMAPWVRTVFINQLPRFLVMRRP-----LYP----ISEMIKSSRRLMVRTCNGLELRDQI 387
            ......::..:|.:..|.:..|.::..|     |:.    |||...|:.
 Worm   416 KHYNKPISDRIRKLIYNPVVEFFILSPPTSLIDLWTEFGVISEQRHSTH---------------- 464

  Fly   388 PPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPT--M 450
              |.|   |...|..|  .|.:|....||              ..|..|:....|.|.|..|  :
 Worm   465 --LDP---LLLQHMDP--ISHTTRADPQH--------------FFGSISSQMCDLQSTYSYTARL 508

  Fly   451 STANQQTSTTSSLIDAQYHNQYQQT 475
            :|..:| .|..:.:.|...|||:.:
 Worm   509 ATITRQ-YTQHAKMKALRKNQYRMS 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	74/228 (32%)
		Cys-loop	150..164	CDD:349832	7/13 (54%)
		LGIC_TM_nAChR	242..>331	CDD:349866	29/95 (31%)
		TM1 helix	242..266	CDD:349866	7/23 (30%)
		TM2 helix	274..295	CDD:349866	6/20 (30%)
		TM3 helix	306..328	CDD:349866	4/24 (17%)
		Neur_chan_memb	<683..760	CDD:460753
acr-5	NP_001367477.1	LIC	104..581	CDD:455710	133/479 (28%)
		Neur_chan_LBD	104..321	CDD:460752	72/225 (32%)