Protein Alignment nAChRalpha3 and acr-5

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 134/480 - (27%)
• Similarity: 218/480 - (45%)
• Gaps: 79/480 - (16%)

  Fly    25 DAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 87
            |.:||.::||  :.|.|.|.|..:.|....|.:.:.|.|::||:...|.:..|:|:.|.|||..|
 Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly    88 KWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTG---------RVEWRPP 143
            .|.|.:||.:....||...||.||..|||:.:...:.|.:.......||         :|:...|
 Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQKKDGAKVQLMFP 232

  Fly   144 AIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWD 208
            ||||.||.:||.:||:|.|.|.....|||:|...:|..   .|:.|      |:|.....:.||:
 Worm   233 AIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYW---PLSST------VNLGNMARNDEWE 288

  Fly   209 ILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSG--- 270
            ::....||.|:.:.||..|::.:..::.:|||.|:|.:||::|...|:.:.:..|:.|:.|.
 Worm   289 VISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSER 353

  Fly   271 -EKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKF---VLFTMILDTFSICVTVLVLNIHFR 331
             ||:.|.|:.||:::|..|::...:|.||..|||:..:   ::..:::.||   :...||.||.:
 Worm   354 DEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTF---LATGVLAIHGQ 415

  Fly   332 SPQTHTMAPWVRTVFINQLPRFLVMRRP-----LYP----ISEMIKSSRRLMVRTCNGLELRDQI 387
            ......::..:|.:..|.:..|.::..|     |:.    |||...|:.
 Worm   416 KHYNKPISDRIRKLIYNPVVEFFILSPPTSLIDLWTEFGVISEQRHSTH---------------- 464

  Fly   388 PPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPT--M 450
              |.|   |...|..|  .|.:|....||              ..|..|:....|.|.|..|  :
 Worm   465 --LDP---LLLQHMDP--ISHTTRADPQH--------------FFGSISSQMCDLQSTYSYTARL 508

  Fly   451 STANQQTSTTSSLIDAQYHNQYQQT 475
            :|..:| .|..:.:.|...|||:.:
 Worm   509 ATITRQ-YTQHAKMKALRKNQYRMS 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	72/225 (32%)
		Neur_chan_memb	248..>359	CDD:280999	29/117 (25%)
		Neur_chan_memb	<683..760	CDD:280999
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	133/479 (28%)
		Neur_chan_LBD	104..321	CDD:397192	72/225 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910