DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and lgc-19

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_502905.2	Gene:	lgc-19 / 190895	WormBaseID:	WBGene00013655	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	92/384 - (23%)
Similarity:	170/384 - (44%)	Gaps:	65/384 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDA-------------LTVRIKLKLSQLIDVNLKNQIMTTNLWV 78
            :.|...:..:|:..|.||....|.             ....|.|...:|::|....:.::..:.:
Worm    35 RNLTKHIFRDYDPTVSPVYTWVDVDLPIGYDNEAPKRYNYTIFLYYLKLVEVQEPQEKISVVMEI 99

  Fly    79 EQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRP--------DIVLYNNADGNFEVTLATKATLNYT 135
            .:.|||.:|.|....:....|:::..|.:|.|        |||.:.:.|...       ..:..|
Worm   100 MEYWYDARLSWNASAWQNTTMIYMKQDKVWSPTISVFGVNDIVDFRDNDNRL-------ICIENT 157

  Fly   136 GRVEWRPPAI-YKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLS 199
            |.: |...:: ..::||:||..||||.|.|.::|....:...|||:     ||  .:.|..:|..
Worm   158 GFI-WDYVSVRVSANCEMDVSRFPFDTQICQIRFCLPIFYRVQVDI-----LN--EIYEEIMDER 214

  Fly   200 EFYT--SVEWDILEV-----PAVRNEKFYTCCDEPYLDIT-FNITMRRKTLFYTVNLIIPCMGIS 256
            .|.|  :.||.:|.:     ..|.|:...|      :|:. |.||:||..|:|...::.|...|:
Worm   215 IFKTMGNSEWKLLNLTNRVEALVYNDNMGT------MDLAIFEITIRRNPLYYIYMIVFPSFIIN 273

  Fly   257 FLTIL-VFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSIC 320
            |::|: ||...:|...::::.::.::::|....::|:.||.|. .:||||.:::..:::...:|.
Worm   274 FVSIVGVFLNGADKMSRLNVGLTNIMTMTFILGVMADKIPRTG-NIPLLGIYIIINLVIMLIAIA 337

  Fly   321 VTVLVLNIH-FRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTC 378
            :...:..:. :.||:....    :|....||..||  .|||...|.:|     |.:.||
Worm   338 IVTAITELRKWASPKLRKK----KTALRAQLESFL--GRPLEYTSAII-----LELMTC 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	58/243 (24%)
		Neur_chan_memb	248..>359	CDD:280999	24/112 (21%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-19	NP_502905.2	LGIC_ECD_cation	75..257	CDD:349790	51/202 (25%)
		LGIC_TM_cation	259..>346	CDD:349853	19/87 (22%)
		TM1 helix	263..284	CDD:349853	6/20 (30%)
		TM2 helix	292..313	CDD:349853	2/20 (10%)
		TM3 helix	323..346	CDD:349853	1/22 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810