DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and acr-24

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001255865.1	Gene:	acr-24 / 190686	WormBaseID:	WBGene00013534	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	128/434 - (29%)
Similarity:	206/434 - (47%)	Gaps:	58/434 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLYDDLLS--NYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWE 90
            ||..||..  .|:..||||:|.:...||...:.|.|::.:|.|.|.:..|:|..|.|.|..|.|.
Worm    34 RLAKDLTDPRRYDSRVRPVMNHSKPTTVSFSMSLYQILSINEKQQNVDLNVWAIQKWNDDFLGWN 98

  Fly    91 PKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT---LATKATLNY----TG-RVEWRPPAIYK 147
            |..||.:....:|.|.||.||..|||:...|.|.|   :....|.||    || .|::..||:|:
Worm    99 PYLYGMINTTILPFDAIWLPDTYLYNSVVMNREETERYINVVVTTNYWKGETGAEVKFMYPALYR 163

  Fly   148 SSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEV 212
            :||.:|:.:||:|:|.|.:...|||  ..:.|:.:..|       ...|::..|..:.||.::..
Worm   164 TSCLLDIRFFPYDQQACKLTISSWT--SSKSDINYEPE-------HESVNMDNFLPNEEWVVVSF 219

  Fly   213 PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFY----LPSDSGEKV 273
            ...|.|:.:.||.||::.:...:.:|||.|:|.|||:||...|:.:.:..|:    ..|:..||:
Worm   220 NIKRVEEKFVCCPEPWVLLEAVLVVRRKPLYYIVNLVIPTSVITLVAVTGFFTAASTSSERREKL 284

  Fly   274 SLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTM 338
            ||.|..||::::..::::|.:|.:|..|||.|.|.|..:.:.......|..:||:|.:......:
Worm   285 SLGIDSLLAMSILMMMVSEQMPTSSDFVPLFGIFYLSIIFIIFIGTLFTAFILNVHLQKMYAKPV 349

  Fly   339 APWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCN------GLELRDQIPPLPPPVALS 397
            :|.|..:|..::.::|.||.|            .:::...|      |.|.:.....:|
Worm   350 SPIVSYIFFGRIAQWLRMRPP------------TMLLELWNETGVTFGKEGQKNSKTIP------ 396

  Fly   398 RMHHS--PKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTIT 439
             .:|.  ||.||.|:..||        |....|.|....|:.|:
Worm   397 -KNHKMIPKVTSSSSGLHL--------LKSNSGSGRAPLAAPIS 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	73/222 (33%)
		Neur_chan_memb	248..>359	CDD:280999	32/114 (28%)
		Neur_chan_memb	<683..760	CDD:280999
acr-24	NP_001255865.1	Neur_chan_LBD	34..248	CDD:280998	73/222 (33%)
acr-24	NP_001255865.1	Neur_chan_memb	255..>411	CDD:280999	43/174 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010