DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-7

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_502777.2	Gene:	lgc-7 / 190370	WormBaseID:	WBGene00013300	Length:	439	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	85/322 - (26%)
Similarity:	161/322 - (50%)	Gaps:	25/322 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWE 90
            |::|.|.|:..|:..:|||.|..|.|.:.|.:....::.::...:.:..:......|.|..|.|.
Worm    28 AEQLKDVLMEGYDSSIRPVNNERDILIINISMNTMSVLTLDPAEETINFSSEFILQWKDEFLFWN 92

  Fly    91 PKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATK-ATLNYTGRVEWRPPAIYKSSCEIDV 154
            ..:| .:..|.:....:|.||..:..:.|.|:.:..:.: .::.:.|.|.....|::.:.|:::|
Worm    93 KSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIDASERYVSVKHDGTVRQSIYAVFTNLCDMNV 156

  Fly   155 EYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEK 219
            :.||:|:|||::|.|.|:|...:|..     :.|.::.....|..:|:.:.|||...:.:...|
Worm   157 DKFPYDQQTCMIKMGPWSYTTQEVTC-----IVGRDIAPNDTDFGDFHGNSEWDFEGIVSSVGE- 215

  Fly   220 FYTCCDEPYLDITFN-----ITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS----GEKVSL 275
                .::|.::.||:     :|::|:..||...|:||...|:.:.|...:.|:.:    .|:|:|
Worm   216 ----TEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFGLFTPTANHGLREERVNL 276

  Fly   276 SISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHT 337
            .|:.|||..|...::|..:|.|| .:||||.|:|..:.:....:...||||.:|.|:   ||
Worm   277 GITTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLFAVLVLTLHQRA---HT 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	51/220 (23%)
		Neur_chan_memb	248..>359	CDD:280999	32/94 (34%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-7	NP_502777.2	LIC	6..437	CDD:273305	85/322 (26%)
		Neur_chan_LBD	28..238	CDD:280998	51/220 (23%)
		Neur_chan_memb	245..>349	CDD:280999	32/94 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810