DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-1

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_504154.5 Gene:lgc-1 / 188099 WormBaseID:WBGene00020236 Length:371 Species:Caenorhabditis elegans


Alignment Length:337 Identity:80/337 - (23%)
Similarity:153/337 - (45%) Gaps:49/337 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 DAKRLYDDLLSNYNKLVRPV--------VN--------VTDALTVRIKLKLSQLIDVNLKNQIMT 73
            |.|||:|||..:|:..:..:        :|        :|:.......|||..:::|..|...:.
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDVVEVEEKVTFLF 79

  Fly    74 TNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGN----FEVTLATK-ATLN 133
            ..|   ..|.|.:|||.|.||||:..::||...||.|::.:   ||.:    ||...|.: |.:|
 Worm    80 DYL---AEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADAHEVKFFESDDAPRTAWIN 138

  Fly   134 YTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDL 198
            |.|...:....:....|::||..||.|...|.:.....||...:..::       :::..:...|
 Worm   139 YNGTTGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIK-------SDMEPLPKPL 196

  Fly   199 SEFYTSVEWDILEV---PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
            |:.... ||.:..:   ..:.|..|...       ..|...:.|...||...:::|...|:||:|
 Worm   197 SQLGNG-EWKVTYIGVAEEIGNGNFSAV-------QRFVARIERNPGFYVTLVMVPAFFINFLSI 253

  Fly   261 LVFYLPSDS-GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVL--FTMILDTFSICVT 322
            :...|..:: |||:::.::.::::|...::||:.:|.|.. :|||..:|:  ..:::.:..:.:|
 Worm   254 IALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTKR-IPLLAIYVIVGLVIVMASIGVVLT 317

  Fly   323 VLVLNIHFRSPQ 334
            :.::..|.:..|
 Worm   318 LPLIRNHLKKRQ 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 57/241 (24%)
Cys-loop 150..164 CDD:349832 6/13 (46%)
LGIC_TM_nAChR 242..>331 CDD:349866 22/91 (24%)
TM1 helix 242..266 CDD:349866 7/23 (30%)
TM2 helix 274..295 CDD:349866 3/20 (15%)
TM3 helix 306..328 CDD:349866 2/23 (9%)
Neur_chan_memb <683..760 CDD:460753
lgc-1NP_504154.5 LIC 84..>335 CDD:455710 64/265 (24%)
Blue background indicates that the domain is not in the aligned region.

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