DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-1

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_504154.5	Gene:	lgc-1 / 188099	WormBaseID:	WBGene00020236	Length:	371	Species:	Caenorhabditis elegans

Alignment Length:	337	Identity:	80/337 - (23%)
Similarity:	153/337 - (45%)	Gaps:	49/337 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DAKRLYDDLLSNYNKLVRPV--------VN--------VTDALTVRIKLKLSQLIDVNLKNQIMT 73
            |.|||:|||..:|:..:..:        :|        :|:.......|||..:::|..|...:.
Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDVVEVEEKVTFLF 79

  Fly    74 TNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGN----FEVTLATK-ATLN 133
            ..|   ..|.|.:|||.|.||||:..::||...||.|::.:   ||.:    ||...|.: |.:|
Worm    80 DYL---AEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADAHEVKFFESDDAPRTAWIN 138

  Fly   134 YTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDL 198
            |.|...:....:....|::||..||.|...|.:.....||...:..::       :::..:...|
Worm   139 YNGTTGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIK-------SDMEPLPKPL 196

  Fly   199 SEFYTSVEWDILEV---PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
            |:.... ||.:..:   ..:.|..|...       ..|...:.|...||...:::|...|:||:|
Worm   197 SQLGNG-EWKVTYIGVAEEIGNGNFSAV-------QRFVARIERNPGFYVTLVMVPAFFINFLSI 253

  Fly   261 LVFYLPSDS-GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVL--FTMILDTFSICVT 322
            :...|..:: |||:::.::.::::|...::||:.:|.|.. :|||..:|:  ..:::.:..:.:|
Worm   254 IALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTKR-IPLLAIYVIVGLVIVMASIGVVLT 317

  Fly   323 VLVLNIHFRSPQ 334
            :.::..|.:..|
Worm   318 LPLIRNHLKKRQ 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	56/238 (24%)
		Neur_chan_memb	248..>359	CDD:280999	21/90 (23%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	64/265 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810