DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-18

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_510029.3 Gene:lgc-18 / 187977 WormBaseID:WBGene00011360 Length:399 Species:Caenorhabditis elegans


Alignment Length:348 Identity:82/348 - (23%)
Similarity:153/348 - (43%) Gaps:85/348 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 RLYDDLLSNYNKLVRPVVNVTDA---------------LTVRI-KLKLSQLIDVNLKNQIMTTNL 76
            :|..|:.:||:..:.||....|.               .||.: .|||.::|:...|..::   |
 Worm    36 KLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPLAPKRFNYTVSLYYLKLVEVIEPEEKVSVV---L 97

  Fly    77 WVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNAD-----------------GNFEV 124
            .:.:.|||.::.|:...||.::|||:..|.:|.|.:.|:...|                 |:...
 Worm    98 EMAEYWYDPRIAWDSSLYGDIKMLHMRQDKVWSPTLSLFRINDIADFRDPDFRMVCVENTGHTYT 162

  Fly   125 TLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFG------------SWTYDGFQ 177
            ||:.|.:||                |.:||..||:|.|||.::|.            |..|:|. 
 Worm   163 TLSVKISLN----------------CPLDVSMFPYDSQTCRIQFNMPLFFMQQVEMFSQIYEGI- 210

  Fly   178 VDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVP-AVRNEKFYTCCDEPYLDITFNITMRRKT 241
                    ||.|...::|        :.||::..:. :|....:.....:..| .||.|.:||..
 Worm   211 --------LNSTVWEKMG--------NSEWELANLTHSVELLSYGDGLGDMQL-ATFEIRIRRNP 258

  Fly   242 LFYTVNLIIPCMGISFLTIL-VFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLG 305
            ::|...:|.|...|:.|:|: ||...:|...|:::.::.::::|....::|:.||.|. .:||||
 Worm   259 MYYIYMIIFPSFIINALSIIGVFLKKTDKMSKLNVGLTNIMTMTFILGVMADKIPKTG-SIPLLG 322

  Fly   306 KFVLFTMILDTFSICVTVLVLNI 328
            .:::..:.:...::.:|:::..|
 Worm   323 IYIIVNLFIMIVAVGLTIVLAEI 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 61/260 (23%)
Cys-loop 150..164 CDD:349832 7/13 (54%)
LGIC_TM_nAChR 242..>331 CDD:349866 21/88 (24%)
TM1 helix 242..266 CDD:349866 8/24 (33%)
TM2 helix 274..295 CDD:349866 2/20 (10%)
TM3 helix 306..328 CDD:349866 1/21 (5%)
Neur_chan_memb <683..760 CDD:460753
lgc-18NP_510029.3 LGIC_ECD_cation 75..257 CDD:349790 53/218 (24%)
Cys-loop 172..186 CDD:349790 7/13 (54%)
LGIC_TM_cation 259..>341 CDD:349853 20/82 (24%)
TM1 helix 259..284 CDD:349853 8/24 (33%)
TM2 helix 292..313 CDD:349853 2/20 (10%)
TM3 helix 323..341 CDD:349853 1/17 (6%)
Blue background indicates that the domain is not in the aligned region.

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