DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-16

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_510027.2	Gene:	lgc-16 / 187975	WormBaseID:	WBGene00011358	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	76/340 - (22%)
Similarity:	151/340 - (44%)	Gaps:	67/340 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KRLYDDLLSNYNKLVRPVV-------------NVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWV 78
            :.|.:||.:||:..:..|.             ...|.....|.|...:|::|....:.::..|.:
Worm    37 ENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLEL 101

  Fly    79 EQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRP--------DIVLYNNADGNFEVTLATKATLNYT 135
            .:.|||.:|.|....|..|..:....:.:|.|        :|:.:.:.|  |.:     .::::|
Worm   102 VERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQD--FRL-----ISIDFT 159

  Fly   136 GRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSE 200
            |.:.........::|.:||..||||.|||.::|....::..||.:                 |:|
Worm   160 GYLNDYLSVRVSANCPMDVSRFPFDSQTCQIRFCLPIFNIRQVKI-----------------LNE 207

  Fly   201 FYTSV------------EWDILEVP-AVRNEKFYTCCDEPY--LDI-TFNITMRRKTLFYTVNLI 249
            .|..:            ||.::.:. .|...|:    |:.|  :|: .|.||:||..|:|...::
Worm   208 IYEGILQEKIIKTMGNSEWKVVSLTNRVEQLKY----DDDYGNMDLAVFEITIRRNPLYYIYMIV 268

  Fly   250 IPCMGISFLTILVFYLPS-DSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMI 313
            .|...|:.::|:..:|.| |...|:::.::.::::|....::|:.||.|. .:||||.:::..::
Worm   269 FPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLL 332

  Fly   314 LDTFSICVTVLVLNI 328
            :...:|.|.||:..:
Worm   333 IMIIAITVVVLITEL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	54/250 (22%)
		Neur_chan_memb	248..>359	CDD:280999	20/82 (24%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	46/209 (22%)
		LGIC_TM	261..>317	CDD:365787	13/55 (24%)
		TM1 helix	261..284	CDD:349850	5/22 (23%)
		TM2 helix	291..315	CDD:349850	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810