DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-15

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_510025.2 Gene:lgc-15 / 187973 WormBaseID:WBGene00011356 Length:399 Species:Caenorhabditis elegans


Alignment Length:405 Identity:92/405 - (22%)
Similarity:180/405 - (44%) Gaps:83/405 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 TIDMILVLSFISSSTANPD--AKRLYD----------DLLSNYNKLVRPV---VNVTDAL----- 51
            |...:..:|.:||...|..  ..:.||          :|.|.|:..:.||   |:.|..|     
 Worm     4 TATFLTYISHVSSIYYNHSLYVPKYYDFLETQTNLTKNLFSGYDATISPVYTKVDPTQPLGHDPD 68

  Fly    52 -----TVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPD 111
                 ...:.|...:|::|....:.::..:.|.:.|:|.:|.|..::|..:..::....::|.|.
 Worm    69 APGRWNYTLLLFSLKLVEVTEPQEKVSVVMEVMEYWFDARLTWNKEDYDDIASIYTRQANVWSPT 133

  Fly   112 I------VLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGS 170
            :      .|.:..|.:|.:...|    :| |.|......:..::|.:||..||||.|||.::|..
 Worm   134 LSAFGVSELVDLRDTDFRLVGIT----SY-GMVNTYVSVLVSANCPMDVYKFPFDYQTCQIRFCI 193

  Fly   171 WTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSV---EWDILEVP-AVRNEKFYTCCDEPY--L 229
            ..:..::|::        .|.:..||..|..:.::   ||:::.:. .|...|:    |:.:  |
 Worm   194 PVFTSYEVEI--------FNEIYAGVLTSNAWKTMGNSEWNLVNLTHRVETLKY----DDGFANL 246

  Fly   230 DI-TFNITMRRKTLFYTVNLIIPCMGISFLTIL-VFYLPSDSGEKVSLSISILLSLTVFFLLLAE 292
            |: ||.|.:||..|:|...:|.|...|:.::|: ||...:|...|:::.::.::::|....::|:
 Worm   247 DLGTFEIKIRRNPLYYIYMIIFPSFIINVVSIIGVFLKGADKMSKLNVGLTNIMTMTFILGVMAD 311

  Fly   293 IIPPTSLVVPLLGKFVLFTMILDTFSI-CVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFL-- 354
            .||.|. .:||||.:::..:::...:| .|||                       ||:|.|..  
 Worm   312 KIPRTG-TIPLLGVYIITNLVIMLIAIGIVTV-----------------------INELRRCASP 352

  Fly   355 VMRRPLYPISEMIKS 369
            |::|....:|..::|
 Worm   353 VLKRKQTKLSRKLES 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 56/255 (22%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 23/90 (26%)
TM1 helix 242..266 CDD:349866 8/24 (33%)
TM2 helix 274..295 CDD:349866 2/20 (10%)
TM3 helix 306..328 CDD:349866 4/22 (18%)
Neur_chan_memb <683..760 CDD:460753
lgc-15NP_510025.2 LGIC_ECD_cation 74..258 CDD:349790 45/200 (23%)
Cys-loop 173..187 CDD:349790 8/13 (62%)
LGIC_TM_cation 260..>343 CDD:349853 23/106 (22%)
TM1 helix 260..285 CDD:349853 8/24 (33%)
TM2 helix 293..314 CDD:349853 2/20 (10%)
TM3 helix 324..343 CDD:349853 4/41 (10%)
Blue background indicates that the domain is not in the aligned region.

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