DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-13

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_510023.2	Gene:	lgc-13 / 187971	WormBaseID:	WBGene00011354	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	353	Identity:	79/353 - (22%)
Similarity:	149/353 - (42%)	Gaps:	61/353 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DLLSNYNKLVRPVV-------------NVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 83
            ||..||.|.|.||.             :........:.|...:||.||...:.::..|.:.:.||
Worm    41 DLFKNYEKDVSPVYAWFDTSKPLGYDPDAPQRYNYTLFLYNLKLIQVNEPEEQVSVVLELMEYWY 105

  Fly    84 DYKLKWEPKEYGGVEMLHVPSDHIWRPDIV------LYNNADGNFEVTLATKATLNY---TGRVE 139
            |.:|.|...:|..|..:....:.||.|.:.      :.:..|.:|.:.......:.|   :.||
Worm   106 DPRLSWNASDYKNVTAIFTRQEKIWSPTLTPFGVNEIIDFRDQDFRLVCIDNLGMIYDYLSVRV- 169

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTS 204
                   .::|.:||..||||.|||.::|....:...:|.: :.:...|.|    ...:.|...:
Worm   170 -------SANCRMDVTKFPFDSQTCQIRFSLPIFSYLEVKI-YTELYEGIN----NYSMFEVMGN 222

  Fly   205 VEWDILEVPAVRNEKFYTCCDEPYLDI-TFNITMRRKTLFYTVNLIIPCMGISFLTIL-VFYLPS 267
            .||:::.:  .....|.|..|...::: .:.|.:.|..|:|...::.|...|:.::|: ||...:
Worm   223 SEWELINL--TNRVDFLTYNDRFDVELAVYEIKIARNPLYYFYMIVFPSFVINSVSIVGVFIKGA 285

  Fly   268 DSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSI-----------CV 321
            |...::::.::.::::|....::::.||.|. .|||||.:::..:::...:|           ||
Worm   286 DKMSRLNVGLTNIMTMTFILGVMSDKIPRTG-NVPLLGIYIIVNLLIMLVAIIIVTIITEIRKCV 349

  Fly   322 TV----------LVLNIHFRSPQTHTMA 339
            |.          |.|.|...||..:|.|
Worm   350 TPKLRKNTSSFNLKLEIFIGSPLEYTCA 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	51/231 (22%)
		Neur_chan_memb	248..>359	CDD:280999	26/114 (23%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-13	NP_510023.2	LGIC_ECD_cation	74..257	CDD:349790	42/197 (21%)
		LGIC_TM	259..>335	CDD:365787	17/76 (22%)
		TM1 helix	259..284	CDD:349850	7/24 (29%)
		TM2 helix	292..313	CDD:349850	1/20 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810