DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and lgc-12

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_498656.3	Gene:	lgc-12 / 187855	WormBaseID:	WBGene00020048	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	341	Identity:	103/341 - (30%)
Similarity:	168/341 - (49%)	Gaps:	33/341 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            :.|...|:.:|.:..|||.|.:..|||.|..::..|::||.:|:.:...:|..|||.|..|.|:|
Worm    30 RELVKHLMKDYYQFTRPVKNYSSMLTVTIMPQIYNLVEVNEQNEQIKLLIWFPQSWKDDYLVWDP 94

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNAD-----GNFEVTLATKATLNYTGRVEWRPPAIYKSSCE 151
            .|:.|:|.:.:|...:|.||..::|..:     .|..|      .::|.|:||.....:....|.
Worm    95 DEWDGIEKITIPKSMVWLPDGYIFNTVEETDTLDNHNV------RVHYNGKVEVDFNKLIDLICP 153

  Fly   152 IDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVR 216
            :.|..||||.|.|.::||||||....:..         ||:|..|  :|...:.||||:...|.:
Worm   154 MSVLSFPFDVQLCALQFGSWTYQSHALSF---------NVLEASV--NENNKNSEWDIVAFNATK 207

  Fly   217 NEKFYTCC---DEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLP----SDSGEKVS 274
            ....|...   |..|.:|.:.:.:|||.|:|.|.::||...|..::.:..:.|    .|..|.||
Worm   208 KVSKYMNLIGGDNVYEEIFYFLEVRRKPLYYIVVILIPTFLIVTVSNIGLFTPHGVHGDREEHVS 272

  Fly   275 LSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMA 339
            |.::.:|::.|...::...:|.:|..:||||.:||....|...::.|:||::..|.|......|.
Worm   273 LGLTTMLTMAVILDMVTGQMPKSSEGIPLLGMYVLIEFALSIMAVLVSVLIIFAHERMLYMDAMP 337

  Fly   340 P-WVRTVFI---NQLP 351
            | |:..:|.   ||:|
Worm   338 PFWIFRLFSKHKNQIP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	67/221 (30%)
		Neur_chan_memb	248..>359	CDD:280999	32/112 (29%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-12	NP_498656.3	Neur_chan_LBD	29..235	CDD:280998	67/221 (30%)
lgc-12	NP_498656.3	Neur_chan_memb	242..>345	CDD:280999	28/102 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810