DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and acr-20

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001367183.1	Gene:	acr-20 / 187632	WormBaseID:	WBGene00000059	Length:	556	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	115/368 - (31%)
Similarity:	190/368 - (51%)	Gaps:	34/368 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTN 75
            :|:|..:...|.:.|...:.:.:|..||..:.|.:.....:.|...::|.|:|.||...|.:..|
Worm     9 VLLLHSLVLLTVSSDQYEIANKILDKYNAGLIPSMGKKSPIEVHFSMELYQIISVNEPQQFLMLN 73

  Fly    76 LWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNA----DGNFEVTLATKATLNYTG 136
            .||.:.|.|..|.|:|:::|.|..:.:|...||.||..|||:.    |.|..:..|...||. .|
Worm    74 AWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDENRRLLHAKVTTLG-EG 137

  Fly   137 R---VEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDE---LNGTNVVEVG 195
            .   :|...|.|||.||.:::.:||||.|:|.:.|||||:|..::|....:|   :..||.:|
Worm   138 NGAFIELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYFAFNESQAIGTTNCIE-- 200

  Fly   196 VDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
                    :..|::|....:|:|..|.||...|..:.|.:|::||.|:|.:|||||...|:|::|
Worm   201 --------NEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINLIIPTSIITFISI 257

  Fly   261 LVFYLPSDSG----EKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFS-IC 320
            :.|:..|...    ||::|.|:.|||:::...::::.:|.||..:||:|.|....::|.:|| ||
Worm   258 IGFFSTSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYTSMILLISFSTIC 322

  Fly   321 VTVLVL---NIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPL 360
            .:|::.   ..:..:|.:.......|.|     .||:.|..||
Worm   323 SSVVIYVQKQGNLGNPPSKNFMNIARAV-----NRFIRMEMPL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	70/224 (31%)
		Neur_chan_memb	248..>359	CDD:280999	35/118 (30%)
		Neur_chan_memb	<683..760	CDD:280999
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	70/224 (31%)
acr-20	NP_001367183.1	LGIC_TM_cation	239..>329	CDD:349853	32/89 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010