DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-30

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_500015.3	Gene:	lgc-30 / 186551	WormBaseID:	WBGene00019069	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	96/413 - (23%)
Similarity:	188/413 - (45%)	Gaps:	62/413 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ANPDAK-----RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQS 81
            |:|||.     ||...:.|:....: |:.:....:.|.|...|.|::|::.:|.:.|.:.:::..
Worm    57 ADPDADGDPHGRLATWIRSHARHHI-PLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSAYLDVH 120

  Fly    82 WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNF-EVTLATKATLNYTGRVEWRPPAI 145
            |.|..:||:|:.:||:|.:.||...||:|:..:|::..|.. :......|.|:|.|.|.......
Worm   121 WNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSVYGRVPDYAPDASAELHYNGLVRMFVSIS 185

  Fly   146 YKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVV--EVGVDLSEFYTSVEWD 208
            .||.|.|:.:.||||.|||....|||.|           :.|..|:|  :..:.|.:||.:.||.
Worm   186 SKSFCPINFKRFPFDSQTCSFSCGSWAY-----------QSNIVNLVAAKQEIALEDFYDNQEWL 239

  Fly   209 ILEV----PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS 269
            :.:.    ...||   .:..:|.:..:...:.::|::.:|..||:.|...:|.:.::.|:.|.::
Worm   240 LTDARLFNGTTRN---VSAANESFSMVYMQLDLKRQSFYYVFNLVFPTTLVSLVAVIGFHAPINA 301

  Fly   270 ----GEKVSLSISILLSLTVFFLLLA-------EIIP---PTSLVVPLLGKFVLFTMILDTFSIC 320
                ..|..|.|..|||::|..|:|.       |.:|   .:...|||:|.:.:..:.:.:.:.|
Worm   302 TGRRESKFRLGIMTLLSMSVMLLMLVGEMKFAMESVPGQRGSFSDVPLMGIYYMTLICIVSIATC 366

  Fly   321 VTVLVLNIH---FRSPQTHTMAPW------VRTVFINQLPRFLVMRRPLYPISEMIKS------- 369
            .:.:.:::.   .|:|...:: ||      .:.:|...:|:.....:..|..:..:::
Worm   367 TSSIFVHLEKFALRNPSWQSV-PWYIRWLAAKKLFCCYVPKSFRYDKDAYSRNNNVQAISLHSTP 430

  Fly   370 ----SRRLMVRTCNGLELRDQIP 388
                ::.|:.:..|..|:....|
Worm   431 DRNVAKNLIPKEINFTEVNQDAP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	59/226 (26%)
		Neur_chan_memb	248..>359	CDD:280999	27/133 (20%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:367255	57/218 (26%)
		LGIC_TM_cation	274..>374	CDD:349853	23/99 (23%)
		TM1 helix	278..298	CDD:349853	5/19 (26%)
		TM2 helix	310..338	CDD:349853	9/27 (33%)
		TM3 helix	352..374	CDD:349853	1/21 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810