DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-30

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_500015.3 Gene:lgc-30 / 186551 WormBaseID:WBGene00019069 Length:529 Species:Caenorhabditis elegans


Alignment Length:413 Identity:96/413 - (23%)
Similarity:188/413 - (45%) Gaps:62/413 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ANPDAK-----RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQS 81
            |:|||.     ||...:.|:....: |:.:....:.|.|...|.|::|::.:|.:.|.:.:::..
 Worm    57 ADPDADGDPHGRLATWIRSHARHHI-PLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSAYLDVH 120

  Fly    82 WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNF-EVTLATKATLNYTGRVEWRPPAI 145
            |.|..:||:|:.:||:|.:.||...||:|:..:|::..|.. :......|.|:|.|.|.......
 Worm   121 WNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSVYGRVPDYAPDASAELHYNGLVRMFVSIS 185

  Fly   146 YKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVV--EVGVDLSEFYTSVEWD 208
            .||.|.|:.:.||||.|||....|||.|           :.|..|:|  :..:.|.:||.:.||.
 Worm   186 SKSFCPINFKRFPFDSQTCSFSCGSWAY-----------QSNIVNLVAAKQEIALEDFYDNQEWL 239

  Fly   209 ILEV----PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS 269
            :.:.    ...||   .:..:|.:..:...:.::|::.:|..||:.|...:|.:.::.|:.|.::
 Worm   240 LTDARLFNGTTRN---VSAANESFSMVYMQLDLKRQSFYYVFNLVFPTTLVSLVAVIGFHAPINA 301

  Fly   270 ----GEKVSLSISILLSLTVFFLLLA-------EIIP---PTSLVVPLLGKFVLFTMILDTFSIC 320
                ..|..|.|..|||::|..|:|.       |.:|   .:...|||:|.:.:..:.:.:.:.|
 Worm   302 TGRRESKFRLGIMTLLSMSVMLLMLVGEMKFAMESVPGQRGSFSDVPLMGIYYMTLICIVSIATC 366

  Fly   321 VTVLVLNIH---FRSPQTHTMAPW------VRTVFINQLPRFLVMRRPLYPISEMIKS------- 369
            .:.:.:::.   .|:|...:: ||      .:.:|...:|:.....:..|..:..:::       
 Worm   367 TSSIFVHLEKFALRNPSWQSV-PWYIRWLAAKKLFCCYVPKSFRYDKDAYSRNNNVQAISLHSTP 430

  Fly   370 ----SRRLMVRTCNGLELRDQIP 388
                ::.|:.:..|..|:....|
 Worm   431 DRNVAKNLIPKEINFTEVNQDAP 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 60/229 (26%)
Cys-loop 150..164 CDD:349832 7/13 (54%)
LGIC_TM_nAChR 242..>331 CDD:349866 23/105 (22%)
TM1 helix 242..266 CDD:349866 6/23 (26%)
TM2 helix 274..295 CDD:349866 9/27 (33%)
TM3 helix 306..328 CDD:349866 1/21 (5%)
Neur_chan_memb <683..760 CDD:460753
lgc-30NP_500015.3 Neur_chan_LBD 68..272 CDD:460752 57/218 (26%)
LGIC_TM_cation 274..>374 CDD:349853 23/99 (23%)
TM1 helix 274..298 CDD:349853 6/23 (26%)
TM2 helix 310..338 CDD:349853 9/27 (33%)
TM3 helix 352..374 CDD:349853 1/21 (5%)
Blue background indicates that the domain is not in the aligned region.

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