DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and acr-21

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001355512.1	Gene:	acr-21 / 185004	WormBaseID:	WBGene00000060	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	212/785 - (27%)
Similarity:	339/785 - (43%)	Gaps:	207/785 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 83
            ||.|:.:..|||.|||.:||..|||.|:..:.:.|.....|:|:|||:.:|||:|||.|:...|.
Worm    24 SSRADQNVMRLYRDLLYDYNNEVRPSVHSKEPINVTFVFSLTQIIDVDERNQILTTNSWIRLHWV 88

  Fly    84 DYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNF-EVTLATKATLNYTGRVEWRPPAIYK 147
            ||||.|:|:.|..|..:|:|||.||:|||:||||||..: :..::|...::|.|.:.|...||:.
Worm    89 DYKLVWDPRLYQNVTRIHIPSDKIWKPDIILYNNADAQYMKSVMSTDVIVDYLGNIHWPLSAIFT 153

  Fly   148 SSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEV 212
            |||.:||:::|||.|||::|:.||.|||.::||....|..         ||:.:.|:.||.::.:
Worm   154 SSCPLDVKHYPFDRQTCILKYASWAYDGTKIDLLLKSEQG---------DLTNYITNTEWSLIGI 209

  Fly   213 PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSI 277
            .|.:|:..|:||.|||..|..::|:.|:.:||..|||:||:.||.:.::.||:|:||||||:|.|
Worm   210 RAEKNQVIYSCCPEPYPFIDVHVTIERRAMFYVFNLILPCVLISLIALMGFYMPTDSGEKVTLGI 274

  Fly   278 SILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWV 342
            :.|||.|||.:::||.:|||:..:||:|.:...|::|......:||..:|||......:.:.|::
Worm   275 TSLLSTTVFLMMVAEGMPPTAEALPLIGIYFGVTIMLVALGTAMTVFTVNIHHTGVHGYPVPPFL 339

  Fly   343 RTVFINQLPRFLVMR-RPLYPISEMIK-----------------SSRRLMVRTCN--------GL 381
            :......|.:.|.:| .|.:.|:..::                 ..:||.....|        ||
Worm   340 QIFAFRYLSKILFVRIEPYHSIAHHVRYMYQKEHPTECTLSASVHYKRLHDFDANVAKKEEQYGL 404

  Fly   382 ELRDQIPPLPPPVALSRMHHSPKTT----SRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGH- 441
            : ||.   ....|..:.:|.:|...    |:|:..:|.......||.....:..|...:...||
Worm   405 Q-RDM---SNLSVISANVHCNPDDRLLLGSQSSQKNLNKFDSEKNLRSSLSIRSGSPTAKKKGHV 465

  Fly   442 -LSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSG 505
             :|::   ..||...:|. .|.|:.....|.:    |:.:|.|:..   |::..|.|||..:...
Worm   466 RVSNI---ARSTRIMETD-VSHLVSFSSLNSH----GTPIDSPIYG---RKLGRTQSQTPTSSYR 519

  Fly   506 NGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNS 570
            |.|||||                    ....||||.              ::||..| |.|.|:.
Worm   520 NSNGNGG--------------------ITSDPLPQQ--------------LSNPPKI-SLTDVDD 549

  Fly   571 VATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTS 635
            |                                            .:..:.||......::....
Worm   550 V--------------------------------------------FENNENQQPMVDEFEKEFLR 570

  Fly   636 AAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQR 700
            ..:..                                                |....|..:|
Worm   571 VMSMV------------------------------------------------HGIIERNEMR-- 585

  Fly   701 WHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAP 765
                            :|::.:::    .:..:|:.|||||||..|.:|.|...:.|. :||...
Worm   586 ----------------VAEKDKRD----AIALEWQQVAMVLDRFLLVVFLIGTSMSTF-VILNQR 629

  Fly   766 TLYDT 770
            .|:::
Worm   630 NLFES 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	91/215 (42%)
		Neur_chan_memb	248..>359	CDD:280999	42/111 (38%)
		Neur_chan_memb	<683..760	CDD:280999	16/76 (21%)
acr-21	NP_001355512.1	LGIC_ECD_nAChR	56..237	CDD:349798	78/189 (41%)
		Cys-loop	156..170	CDD:349798	7/13 (54%)
		LGIC_TM_cation	239..>327	CDD:349853	40/87 (46%)
		TM1 helix	239..263	CDD:349853	11/23 (48%)
		TM2 helix	271..292	CDD:349853	10/20 (50%)
		TM3 helix	303..325	CDD:349853	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810