Protein Alignment nAChRalpha3 and acr-21

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001355512.1
• Gene: acr-21 / 185004
• WormBaseID: WBGene00000060
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 785
• Identity: 212/785 - (27%)
• Similarity: 339/785 - (43%)
• Gaps: 207/785 - (26%)

  Fly    19 SSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 83
            ||.|:.:..|||.|||.:||..|||.|:..:.:.|.....|:|:|||:.:|||:|||.|:...|.
 Worm    24 SSRADQNVMRLYRDLLYDYNNEVRPSVHSKEPINVTFVFSLTQIIDVDERNQILTTNSWIRLHWV 88

  Fly    84 DYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNF-EVTLATKATLNYTGRVEWRPPAIYK 147
            ||||.|:|:.|..|..:|:|||.||:|||:||||||..: :..::|...::|.|.:.|...||:.
 Worm    89 DYKLVWDPRLYQNVTRIHIPSDKIWKPDIILYNNADAQYMKSVMSTDVIVDYLGNIHWPLSAIFT 153

  Fly   148 SSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEV 212
            |||.:||:::|||.|||::|:.||.|||.::||....|..         ||:.:.|:.||.::.:
 Worm   154 SSCPLDVKHYPFDRQTCILKYASWAYDGTKIDLLLKSEQG---------DLTNYITNTEWSLIGI 209

  Fly   213 PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSI 277
            .|.:|:..|:||.|||..|..::|:.|:.:||..|||:||:.||.:.::.||:|:||||||:|.|
 Worm   210 RAEKNQVIYSCCPEPYPFIDVHVTIERRAMFYVFNLILPCVLISLIALMGFYMPTDSGEKVTLGI 274

  Fly   278 SILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWV 342
            :.|||.|||.:::||.:|||:..:||:|.:...|::|......:||..:|||......:.:.|::
 Worm   275 TSLLSTTVFLMMVAEGMPPTAEALPLIGIYFGVTIMLVALGTAMTVFTVNIHHTGVHGYPVPPFL 339

  Fly   343 RTVFINQLPRFLVMR-RPLYPISEMIK-----------------SSRRLMVRTCN--------GL 381
            :......|.:.|.:| .|.:.|:..::                 ..:||.....|        ||
 Worm   340 QIFAFRYLSKILFVRIEPYHSIAHHVRYMYQKEHPTECTLSASVHYKRLHDFDANVAKKEEQYGL 404

  Fly   382 ELRDQIPPLPPPVALSRMHHSPKTT----SRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGH- 441
            : ||.   ....|..:.:|.:|...    |:|:..:|.......||.....:..|...:...||
 Worm   405 Q-RDM---SNLSVISANVHCNPDDRLLLGSQSSQKNLNKFDSEKNLRSSLSIRSGSPTAKKKGHV 465

  Fly   442 -LSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSG 505
             :|::   ..||...:|. .|.|:.....|.:    |:.:|.|:..   |::..|.|||..:...
 Worm   466 RVSNI---ARSTRIMETD-VSHLVSFSSLNSH----GTPIDSPIYG---RKLGRTQSQTPTSSYR 519

  Fly   506 NGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNS 570
            |.|||||                    ....||||.              ::||..| |.|.|:.
 Worm   520 NSNGNGG--------------------ITSDPLPQQ--------------LSNPPKI-SLTDVDD 549

  Fly   571 VATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTS 635
            |                                            .:..:.||......::....
 Worm   550 V--------------------------------------------FENNENQQPMVDEFEKEFLR 570

  Fly   636 AAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQR 700
            ..:..                                                |....|..:|
 Worm   571 VMSMV------------------------------------------------HGIIERNEMR-- 585

  Fly   701 WHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAP 765
                            :|::.:::    .:..:|:.|||||||..|.:|.|...:.|. :||...
 Worm   586 ----------------VAEKDKRD----AIALEWQQVAMVLDRFLLVVFLIGTSMSTF-VILNQR 629

  Fly   766 TLYDT 770
            .|:::
 Worm   630 NLFES 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	91/218 (42%)
		Cys-loop	150..164	CDD:349832	7/13 (54%)
		LGIC_TM_nAChR	242..>331	CDD:349866	41/88 (47%)
		TM1 helix	242..266	CDD:349866	11/23 (48%)
		TM2 helix	274..295	CDD:349866	10/20 (50%)
		TM3 helix	306..328	CDD:349866	4/21 (19%)
		Neur_chan_memb	<683..760	CDD:460753	16/76 (21%)
acr-21	NP_001355512.1	LGIC_ECD_nAChR	56..237	CDD:349798	78/189 (41%)
		Cys-loop	156..170	CDD:349798	7/13 (54%)
		LGIC_TM_cation	239..>327	CDD:349853	40/87 (46%)
		TM1 helix	239..263	CDD:349853	11/23 (48%)
		TM2 helix	271..292	CDD:349853	10/20 (50%)
		TM3 helix	303..325	CDD:349853	4/21 (19%)