Protein Alignment nAChRalpha3 and lgc-6

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_501410.3
• Gene: lgc-6 / 184621
• WormBaseID: WBGene00017544
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 382
• Identity: 84/382 - (21%)
• Similarity: 184/382 - (48%)
• Gaps: 50/382 - (13%)

  Fly     1 MKWFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDV 65
            |.|.   :..:..::|:.:|......::|::   ..|:..::|    :|.||: :.:..:..|.:
 Worm     1 MLWI---LRFLTAVAFLETSNTETLLQQLFN---QTYDVDMKP----SDDLTM-VTITPNTFILL 54

  Fly    66 NLKNQIMTTNLWVEQ---SWYDYKLKWEPK--EYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT 125
            :: :|...|..:.|:   .|||..|.|...  .|.. :.:.:.:...|.||::..|..|.:   .
 Worm    55 SM-DQTQETIQYSEEFLLRWYDPILHWNQSAVSYEN-DWIKISASRAWIPDVIFTNGIDMD---P 114

  Fly   126 LATK----ATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDEL 186
            |..|    |.|.|.|.:....||:..|.|.::::.||:|.|.|.:..|||.:|...:.::
 Worm   115 LLDKDMQMADLRYNGEIRTSRPAVVSSPCPLEIDNFPYDVQKCNISMGSWAFDRRFLSVQ----- 174

  Fly   187 NGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIP 251
              ::.:|:......|..:.||:::.:..||::.:.|..:|.:.:||:.:|::||.::|.:.:..|
 Worm   175 --SSTIEILPQKGRFEGNSEWELISILTVRSDSYDTLLEEWFSEITYVVTLKRKPVYYVLVIQAP 237

  Fly   252 CMGISFLTILVFYLPSDSGE----KVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTM 312
            ...:..:||...:.|:.:.:    ||.|.:::..::::...|:::::|..|. :||||.:::..:
 Worm   238 TFILCTITIFGLFTPNSNEDERLSKVELCLNMFAAISMMLQLVSDMMPKASR-LPLLGNYIIAEI 301

  Fly   313 ILDTFSICVTVLVLNIHFRSPQTHTMA----PWVRTVFINQLPRFLVMRRPLYPISE 365
            .:.|.:...::::...|.   ..||.|    .|:|.:.:.:      .||..:.|||
 Worm   302 FVVTAATIASIIIQQTHH---HVHTSAIRPRRWLRCLVLCE------CRRRRFSISE 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	52/223 (23%)
		Neur_chan_memb	248..>359	CDD:280999	22/118 (19%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-6	NP_501410.3	LIC	1..424	CDD:273305	84/382 (22%)
		LGIC_ECD_cation	42..226	CDD:349790	46/196 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810